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Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 4, pp 430–433 | Cite as

Sex Differences in the Production of SLC5A5, Thyroid Peroxidase, and Thyroid Hormones in Pubertal Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Postnatal Ontogeny

  • N. V. Yaglova
  • Yu. P. Sledneva
  • S. V. Nazimova
  • S. S. Obernikhin
  • V. V. Yaglov
Article
  • 27 Downloads

Sex differences in the expression of iodide transporter SLC5A5 and thyroid peroxidase in thyroid follicular epithelium and thyroid serum profile were assessed in pubertal rats exposed to endocrine disruptor DDT starting from the first postnatal day. It was found that exposure to DDT reduced expression of SLC5A5 in peripheral regions of thyroid lobes in males and in central regions in females. The most pronounced sex differences were observed in thyroid peroxidase expression that remained sensitive to thyroid stimulating hormone regulation in males and lost sensitivity to pituitary stimulation in females after exposure to disruptor, which determines more pronounced hypothyroidism in females.

Key Words

SLC5A5 thyroid peroxidase thyroid gland endocrine disruptors DDT sex differences 

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References

  1. 1.
    SanPiN 2.3.2.1078-01. Hygienic Requirements to Foodstuff Safety and Nutritive Value, Moscow, 2008. Russian.Google Scholar
  2. 2.
    Yaglova NV. Disorders in the secretory cycle of follicular thyrocytes and their correction with thyrotropic hormone in experimental non-thyroidal illness syndrome. Bull. Exp. Biol. Med. 2011;152(2):253-257.CrossRefPubMedGoogle Scholar
  3. 3.
    Yaglova NV, Yaglov VV. Mechanisms of Disruptive Action of Dichlorodiphenyltrichloroethane (DDT) on the Function of Thyroid Follicular Epitheliocytes. Bull. Exp. Biol. Med. 2015;160(8):231-233.CrossRefPubMedGoogle Scholar
  4. 4.
    Yaglova NV, Yaglov VV. Alteration of thyroid hormone secretion after long-term exposure to low doses of endocrine disruptor DDT. Biomed. Khimiya. 2014;60(6):655-660.CrossRefGoogle Scholar
  5. 5.
    Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, Zoeller RT, Gore AC. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr. Rev. 2009;30(4):293-342.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Endocrine Pathology. Differential Diagnosis and Molecular Advances. Lloyd RV, ed. New York, 2010.Google Scholar
  7. 7.
    Levy O, Dai G, Riedel C, Ginter CS, Paul EM, Lebowitz AN, Carrasco N. Characterization of the thyroid Na/I-symporter with an anti-COOH terminus antibody. Proc. Natl Acad. Sci. USA. 1997;94(11):5568-5573.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    McGrogan A, Seaman HE, Wright JW, de Vries CS. The incidence of autoimmune thyroid disease: a systematic review of the literature. Clin. Endocrinol. (Oxf). 2008;69(5):687-696.CrossRefPubMedGoogle Scholar
  9. 9.
    Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT, Myers JP. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr. Rev. 2012;33(3):378-455.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. V. Yaglova
    • 1
  • Yu. P. Sledneva
    • 1
  • S. V. Nazimova
    • 1
  • S. S. Obernikhin
    • 1
  • V. V. Yaglov
    • 1
  1. 1.Research Institute of Human MorphologyMoscowRussia

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