Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 3, pp 404–407 | Cite as

Experimental Modeling of Alcohol-Induced Liver Cirrhosis in Rats

  • A. E. Antushevich
  • A. E. Antushevich
  • A. N. Grebenyuk
  • D. A. Khalyutin
  • A. A. Yartseva
Article
  • 19 Downloads

An experimental model of alcohol-induced liver cirrhosis in white outbred rats was developed: intragastric administration of 40% ethanol (3 g/kg) every other day for 3 weeks and simultaneous intraperitoneal administration of 1% of N-nitrozodimethylamine (5 mg/kg) for 4 consecutive days of each week.

Key Words

cirrhosis ethanol dimethylnitrosamine rats 

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References

  1. 1.
    Arutyunyan IV, Makarov AV, Fathudinov TH, Bolshakova GB. Liver cirrhosis models in laboratory animals. Klin. Eksp. Morfol. 2012(2):45-50. Russian.Google Scholar
  2. 2.
    Dolgushina AI, Olevskaya YeR, Tarasov AN, Kazakova MS, Markina AYu. Liver cirrhosis epidemiology in Chelyabinsk region in 2006-2015. Ross. Zh. Gastroenterol. Gepatol., Koloproktol. 2017;27(1):72-78. Russian.Google Scholar
  3. 3.
    Manual for Preclinical Studies of New Pharmacological Substances. Part I, Mironov AN, ed. Moscow, 2012. Russian.Google Scholar
  4. 4.
    Constandinou C, Henderson N, Iredale JP. Modeling liver fibrosis in rodents. Methods Mol. Med. 2005;117:237-250.PubMedGoogle Scholar
  5. 5.
    Jin Y. L, Enzan H, Kuroda N, Hayashi Y, Nakayama H, Zhang YH, Toi M, Miyazaki E, Hiroi M, Guo LM, Saibara T. Tissue remodeling following submassive hemorrhagic necrosis in rat livers induced by an intraperitoneal injection of dimethylnitrosamine. Virchows Arch. 2003;442(1):39-47.PubMedGoogle Scholar
  6. 6.
    Mokdad AA, Lopez AD, Shahraz S, Lozano R, Mokdad AH, Stanaway J, Murray CJ, Naghavi M. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med. 2014;12:145. doi:  https://doi.org/10.1186/s12916-014-0145-y.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • A. E. Antushevich
    • 1
  • A. E. Antushevich
    • 1
  • A. N. Grebenyuk
    • 1
  • D. A. Khalyutin
    • 1
  • A. A. Yartseva
    • 1
  1. 1.S. M. Kirov Military Medical Academy of the Ministry of Defense of the Russian FederationSt. PetersburgRussia

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