Dynamics of Distribution of Capillaries with Matrix Metalloproteinase-2 and Its Tissue Inhibitor in Rat Brain during Development of Experimental Hypertension
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The capillaries containing MMP-2 and its tissue inhibitor TIMP-2 were examined in cerebral cortex and white matter obtained from intact Wistar rats (n=5) and the rats with progressing experimental renovascular hypertension (n=35). In hypertensive rats, the changes in intensity of the immunohistochemical reaction and in the density of capillaries expressing TIMP-2 significantly differed from the corresponding values in MMP-2-positive capillaries, which resulted in pronounced deviation of MMP-2/TIMP-2 index from the control level (especially in cerebral cortex) probably attesting to enhanced risk of complications in cases with arterial hypertension.
Key Wordscerebral capillaries immunolocalization of MMP-2 and TIMP-2 renovascular hypertension
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- 1.Miromanova NA, Miromanov AM. Changes in the system “matrix metalloprotease — inhibitor of matrix metalloprotease” at children’s influenza. Fundament. Issled. 2014(10-2):328-332. Russian.Google Scholar
- 3.Poteriaeva ON. Matrix metalproteinases: structure, regulation, role in pathological states development (literature review). Meditsina Obrazovanie Sibiri. 2010(5):7-17. Russian.Google Scholar
- 4.Chertok VM. Mast cells of the outer sheath of cerebral basilar arteries. Morfologiya. 1980;79(11):72-79. Russian.Google Scholar
- 5.Chertok VM, Startseva МS, Kotsyuba AYe. The application of a “pixel method” for the quantitative assessment of the results of the histochemical studies. Morfologiya. 2012;142(5):71-75. Russian.Google Scholar
- 6.Chertok VM, Chertok AG. Regulatory capacity of the brain capillaries. Tikhookean. Med. Zh. 2016(2):72-80. Russian.Google Scholar
- 12.Hiller O, Lichte A, Oberpichler A, Kocourek A, Tschesche H. Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII. J. Biol. Chem. 2000;275(42):33 008-33 013.CrossRefGoogle Scholar