Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 3, pp 397–401 | Cite as

Dynamics of Distribution of Capillaries with Matrix Metalloproteinase-2 and Its Tissue Inhibitor in Rat Brain during Development of Experimental Hypertension

  • V. M. ChertokEmail author
  • A. G. Chertok
  • N. V. Zakharchuk
  • V. A. Nevzorova

The capillaries containing MMP-2 and its tissue inhibitor TIMP-2 were examined in cerebral cortex and white matter obtained from intact Wistar rats (n=5) and the rats with progressing experimental renovascular hypertension (n=35). In hypertensive rats, the changes in intensity of the immunohistochemical reaction and in the density of capillaries expressing TIMP-2 significantly differed from the corresponding values in MMP-2-positive capillaries, which resulted in pronounced deviation of MMP-2/TIMP-2 index from the control level (especially in cerebral cortex) probably attesting to enhanced risk of complications in cases with arterial hypertension.

Key Words

cerebral capillaries immunolocalization of MMP-2 and TIMP-2 renovascular hypertension 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • V. M. Chertok
    • 1
    Email author
  • A. G. Chertok
    • 1
  • N. V. Zakharchuk
    • 2
  • V. A. Nevzorova
    • 2
  1. 1.Department of Human AnatomyVladivostokRussia
  2. 2.Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian FederationVladivostokRussia

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