Clinical and morphological investigation of myelofibrosis was performed in patients with chronic myeloid leukemia, multiple myeloma, and chronic lymphocytic leukemia by analyzing the morphometric parameters of trepan-biopsy material. The correlation between changes in the parameters of erythron system and distribution of myelofibrosis were analyzed. In patients with chronic myeloid leukemia, multiple myeloma, and chronic lymphocytic leukemia, the maximum suppression of the erythron was observed against the background of severe myelofibrosis. The degree of erythron inhibition correlated with distribution of the fibrous tissue in the bone marrow. In patients with onset of chronic phase of chronic myeloid leukemia and active phase of multiple myeloma, the total number of erythroid cells was lower than in active phase of chronic lymphocytic leukemia irrespective of the degree of myelofibrosis. Erythrocyte count and hemoglobin content in the peripheral blood were lower in patients with multiple myeloma and chronic lymphocytic leukemia in comparison with the corresponding parameters in patients with chronic myeloid leukemia irrespective of the severity of myelofibrosis.
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References
Anemia of Chronic Disease. Manual for Hematology. Vol. 3. Vorob’ev AI, ed. Moscow, 2005. P. 313-322. Russian.
Babicheva LG, Poddubnaya IV. Anemia and methods of its correction in cancer patients. Sovremen. Onkol. 2010;(3):89-93. Russian.
Dolgikh TY, Sholenberg EV, Kachesov IV, Domnikova NP, Klinnikova MG. Clinical Morphological Studies of Myelofibrosis with Different Types of Bone Marrow Involvement in Patients with Chronic Lymphocytic Leukemia. Bull. Exp. Biol. Med. 2016;161(3):408-411.
Domnikova NP, Dolgikh TYu. Prevalence of myelofibrosis in chronic myeloid leukemia, multiple myeloma and chronic lymphocytic leukemia in different phases of diseases. Sib. Nauch. Med. Zh. 2016;36(5):53-57. Russian.
Domnikova NP, Nepomnyashchikh GI, Dolgikh TYu, Petrusenko EE, Kachesov IV. Morphological study of trephine biopsies in non-Hodgkin’s lymphomas. Sib. Onkol. Zh. 2011;(3):45-50. Russian.
Mendeleeva LP, Votyakova OM, Pokrovskaya OS, Rekhtina IG, Bessmel’tsev SS, Golubeva ME, Darskaya EI, Zagoskina TP, Zinina EE, Kaplanov KD, Konstantinova TS, Kryuchkova IV, Medvedeva NV, Motorin SV, Pospelova TI, Ryzhko VV, Samoilova OS, Urnova ES, Savchenko VG. National clinical guidelines for the diagnosis and treatment of multiple myeloma. Gematol. Transfuziol. 2014;59(S3):2-24. Russian.
Pavlov AD, Morshchakova EF, Rumyantsev AG. Erythropoiesis, Erythropoietin, and Iron. Moscow, 2011. Russian.
Treatment Protocols for Blood Diseases. Savchenko VG, ed. Moscow, 2012. Russian.
Saraeva NO. Mechanisms of anemia development in hematological malignancies. Gematol. Transfuziol. 2007;52(1):31-37. Russian.
Saraeva NO, Gorokhova LA, Khoroshih OV, Musinzeva JaA, Zagorodnaya AN. Mechanisms of development of anemia at patients with a multiple myeloma. Sib. Med. Zh. (Irkutsk). 2006;65(7):28-30. Russian.
State of Cancer Care in Russia in 2015. Karpin AD, Starinskii VV, Petrova GV, eds. Moscow, 2016. Russian.
Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating MJ, Montserrat E, Rai KR, Kipps TJ; International Workshop on Chronic Lymphocytic Leukemia. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111(12):5446-5456.
Mauro FR, Foa R, Cerretti R, Giannarelli D, Coluzzi S, Mandelli F, Girelli G. Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features. Blood. 2000;95(9):2786-2792.
Tadmor T, Shvidel L, Aviv A, Ruchlemer R, Bairey O, Yuklea M, Herishanu Y, Braester A, Rahimi-Levene N, Vernea F, Ben-Ezra J, Bejar J, Polliack A; Israeli CLL Study Group. Significance of bone marrow reticulin fibrosis in chronic lymphocytic leukemia at diagnosis: a study of 176 patients with prognostic implications. Cancer. 2013;119(10):1853-1859.
Thiele J, Kvasnicka HM, Facchetti F, Franco V, van der Walt J, Orazi A. European consensus on grading bone marrow fibrosis and assessment of cellularity. Haematologica. 2005;90(8):1128-1132.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 9, pp. 367-371, September, 2017
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Dolgikh, T.Y., Sholenberg, E.V., Kachesov, I.V. et al. Connection between Parameters of Erythron System and Myelofibrosis during Chronic Myeloleukemia, Multiply Mieloma, and Chronic Lymphatic Leukemia. Bull Exp Biol Med 164, 382–385 (2018). https://doi.org/10.1007/s10517-018-3994-0
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DOI: https://doi.org/10.1007/s10517-018-3994-0