Specific Features of Immediate Ultrastructural Changes in Brain Cortex Mitochondria of Rats with Different Tolerance to Hypoxia under Various Modes of Hypoxic Exposures
- 32 Downloads
We performed ultrastructural study of cerebral cortex mitochondria in rats with different tolerance to oxygen deficiency (low resistant and highly resistant specimens). Low resistant rats were characterized by the prevalence of mitochondria with lightened matrix due to the nondense packing of cristae. By contrast, mitochondria of highly resistant animals had the dense packing of cristae. The structure of mitochondria underwent adaptive changes at 14-10% O2 in the inspired air. Under these conditions, structural characteristics of the cerebral cortex in hypoxia-sensitive rats resembled those in resistant animals. The decrease in O2 concentration to 8% was accompanied by ultrastructural signs of mitochondrial damage, which correlated with de-energization of the cell and dysfunction of adaptive signaling systems. Ultrastructural features of cerebral cortex mitochondria in animals with low and high tolerance to acute oxygen deficiency confirm the hypothesis that they are associated with two different “functionaland-metabolic portraits”.
Key Wordscerebral cortex hypoxia mitochondria ultrastructure
Unable to display preview. Download preview PDF.
- 2.Zabolotskii NN, Onishchenko LS, Gakeev ISh. Mitochondrial megacone and pleiocone in the brain of rats as a possible adaptive response to lethal radiation and radiomodifying damage. Morfologiya. 1999;115(3):27-31. Russian.Google Scholar
- 3.Ivanchenko MV, Tverdokhleb IV. The impact of intrauterine hypoxia on mitochondrial heterogeneity which is controlled through alterations in rat ventricular myocardium. Vestn. Bolgograd. Gos. Med. Univer. 2014(4):101-106. Russian.Google Scholar
- 8.Sukhorukov VS. Essay on mitochondrial pathology. Moscow, 2011. Russian.Google Scholar
- 10.Chen H, Chomyn A, Chan DC. Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J. Biol. Chem. 2005;280(28):26 185-26 192.Google Scholar
- 15.Wiesner RJ, Hornung TV, Garman JD, Clayton DA, O’Gorman E, Wallimann T. Stimulation of mitochondrial gene expression and proliferation of mitochondria following impairment of cellular energy transfer by inhibition of the phosphocreatine circuit in rat hearts. J. Bioenerg. Biomembr. 1999;31(6):559-567.CrossRefPubMedGoogle Scholar