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Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 3, pp 362–365 | Cite as

Potentiation of Otoprotective Effect of Hydrocortisone Immobilized on Povidone Nanoparticles under Conditions of Intravenous Injection

BIOTECHNOLOGIES
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The otoprotective effect of immobilized hydrocortisone was studied on the model of acute acoustic injury to the auditory analyzer in male Wistar rats. The effects of true solution and suspension where polyvinylpyrrolidone particles (100-500 nm) served as dispersed phase (hydrocortisone concentration 5 mg/kg). The agents were administered immediately after continuous acoustic stimulation: 5 kHz tone, 110 dB for 2 h. The hearing status was evaluated by the amplitude of otoacoustic emission at the distortion product frequency (4-6.4 kHz) 1 and 24 h and 7 days after acoustic stimulation. Single injection of hydrocortisone suspension caused a more pronounced therapeutic effect within 1 day after acoustic stimulation.

Key Words

drug delivery systems 100-500 nm nanoparticles povidone hydrocortisone suspension otoprotection 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.V. A. Almazov National Medical Research CenterMinistry of Health of the Russian FederationSt. PetersburgRussia
  2. 2.I. P. Pavlov First St. Petersburg State Medical UniversityMinistry of Health of the Russian FederationSt. PetersburgRussia

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