Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 3, pp 347–350 | Cite as

Inactivation of M111 Protein Gene Modifies Streptococcus Pyogenes Interactions with Mouse Macrophages In Vitro

  • M. A. Suvorova
  • T. A. Kramskaya
  • A. N. Suvorov
  • E. P. Kiseleva

Immunomodulatory properties of S. pyogenes protein M111 were studied on the model of Gurov strain and its isogenic mutant not expressing M protein. Mouse resident peritoneal macrophages were incubated with bacteria and generation of nitroxide and superoxide anions and production of IL-6, IL-10, and IL-17 were evaluated. Protein M111 modified macrophage response: it exhibited antiphagocytic activity, prevented ROS formation, and stimulated the production of anti-inflammatory cytokine IL-10. The results suggested that this protein could serve in the bacteria as a factor suppressing the host defense forces and promoting the realization of the strategy beneficial for pathogens — escape from the host immune defense.

Key Words

Streptococcus pyogenes M protein macrophages superoxide radicals cytokines 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • M. A. Suvorova
    • 1
  • T. A. Kramskaya
    • 1
  • A. N. Suvorov
    • 1
  • E. P. Kiseleva
    • 1
    • 2
  1. 1.Institute of Experimental MedicineSt. PetersburgRussia
  2. 2.I. I. Mechnikov North-Western State Medical UniversitySt. PetersburgRussia

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