Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 3, pp 320–323 | Cite as

Signal Mechanism of the Protective Effect of Combined Preconditioning by Amtizole and Moderate Hypoxia

  • O. S. Levchenkova
  • V. E. Novikov
  • E. S. Abramova
  • Zh. A. Feoktistova

The content of regulatory proteins involved in adaptation to hypoxia and ischemia was studied in brain rat homogenate under conditions of normoxia and after bilateral ligation of the common carotid arteries. Preconditioning with amtizole in combination with moderate hypoxia increased the levels of HIF-1α, erythropoietin, vascular endothelial growth factor under conditions of normoxia. During experimental ischemia, combined preconditioning led to stabilization of the content of these regulatory proteins at the level of intact control and to a decrease in glycogen synthase-3β kinase activity. This pattern of changes in regulatory proteins was noted during the early and late periods of preconditioning.

Key Words

preconditioning HIF-1α erythropoietin vascular endothelial growth factor glycogen synthase-3β kinase 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • O. S. Levchenkova
    • 1
  • V. E. Novikov
    • 1
  • E. S. Abramova
    • 1
  • Zh. A. Feoktistova
    • 1
  1. 1.Department of PharmacologySmolensk State Medical UniversitySmolenskRussia

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