Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 3, pp 298–303 | Cite as

The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia

  • L. D. Lukyanova
  • Yu. I. Kirova
  • E. L. Germanova

Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.

Key Words

succinate HIF-1α GABA shunt hypoxia 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • L. D. Lukyanova
    • 1
  • Yu. I. Kirova
    • 1
  • E. L. Germanova
    • 1
  1. 1.Research Institute of General Pathology and PathophysiologyMoscowRussia

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