Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 3, pp 293–297 | Cite as

Inducible NO Synthase mRNA Expression and Infiltration of Rats Myocardium with Inflammatory Cells in 2-4 Hours after Modeled Permanent Ischemia or Ischemia/Reperfusion

  • E. V. Ivanov
  • A. B. Berdalin
  • Yu. L. Volkova
  • M. A. Markov
  • M. P. Davydova
  • S.A. Gavrilova
GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
  • 21 Downloads

Expression of inducible NO-synthase mRNA and myocardial infiltration with neutrophils were studied in rats with modeled permanent ischemia and ischemia/reperfusion models. Expression of inducible NO synthase mRNA in the ischemic region increased significantly in 3, 3.5, and 4 h in modeled ischemia/reperfusion and in 3.5 and 4 h in permanent ischemia. Myocardial infiltration with neutrophils was significantly higher than in intact controls throughout the experiment without significant intergroup differences. In non-ischemic myocardium, enhanced expression of inducible NO synthase mRNA and moderate neutrophilic-lymphocytic myocardial infiltration were also observed in 3.5, and 4 h after ischemia.

Key Words

nitric oxide inducible NO synthase myocardial ischemia myocardial infiltration 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • E. V. Ivanov
    • 1
  • A. B. Berdalin
    • 1
  • Yu. L. Volkova
    • 1
  • M. A. Markov
    • 1
  • M. P. Davydova
    • 1
  • S.A. Gavrilova
    • 1
  1. 1.Faculty of Fundamental MedicineM. V. Lomonosov Moscow State UniversityMoscowRussia

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