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DAI-1 Receptor Expression in Placenta in Earlyand Late-Onset Preeclampsia

  • MORPHOLOGY AND PATHOMORPHOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

DAI-1 receptor (DNA-dependent activator of IFN-regulatory factors; DLM-1/ZBP-1) is an innate immunity cytoplasmic receptor of the DNA-recognition receptor class of antiviral immunity. DAI-1 expression reflects the severity of the inflammatory response that plays the key role in the pathogenesis of pregnancy complications. We studied DAI-1 receptor expression in the placental villi in early- and late-onset preeclampsia. In case of early-onset preeclampsia DAI-1 staining intensity was lower (p=0.01), and in case of late preeclampsia — significantly higher (p<0.005) than in the reference groups at the corresponding gestational age. There was revealed a correlation between the decrease in DAI-1 receptor expression and the severity of disease progression.

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Authors and Affiliations

  1. V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    N. V. Nizyaeva, G. V. Kulikova, M. N. Nagovitsyna, G. V. Khlestova, M. N. Yushina, O. R. Baev & A. I. Shchegolev

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  1. N. V. Nizyaeva
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  2. G. V. Kulikova
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  3. M. N. Nagovitsyna
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  4. G. V. Khlestova
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  5. M. N. Yushina
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  6. O. R. Baev
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  7. A. I. Shchegolev
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Correspondence to N. V. Nizyaeva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 7, pp. 127-132, July, 2017

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Nizyaeva, N.V., Kulikova, G.V., Nagovitsyna, M.N. et al. DAI-1 Receptor Expression in Placenta in Earlyand Late-Onset Preeclampsia. Bull Exp Biol Med 164, 109–114 (2017). https://doi.org/10.1007/s10517-017-3936-2

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  • DOI: https://doi.org/10.1007/s10517-017-3936-2

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