Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 563–568 | Cite as

Reconstruction of Ligament and Tendon Defects Using Cell Technologies

  • R. K. Chailakhyan
  • A. B. Shekhter
  • S. V. Ivannikov
  • V. I. Tel’pukhov
  • D. S. Suslin
  • Yu. V. Gerasimov
  • A. M. Tonenkov
  • A. G. Grosheva
  • P. V. Panyushkin
  • I. L. Moskvina
  • N. N. Vorob’eva
  • V. N. Bagratashvili
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • 85 Downloads

We studied the possibility of restoring the integrity of the Achilles tendon in rabbits using autologous multipotent stromal cells. Collagen or gelatin sponges populated with cells were placed in a resorbable Vicryl mesh tube and this tissue-engineered construct was introduced into a defect of the middle part of the Achilles tendon. In 4 months, histological analysis showed complete regeneration of the tendon with the formation of parallel collagen fibers, spindle-shaped tenocytes, and newly formed vessels.

Key Words

ligaments and tendons multipotent stromal cells regeneration tissue-engineered construct 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • R. K. Chailakhyan
    • 1
  • A. B. Shekhter
    • 2
  • S. V. Ivannikov
    • 2
  • V. I. Tel’pukhov
    • 2
  • D. S. Suslin
    • 2
  • Yu. V. Gerasimov
    • 1
  • A. M. Tonenkov
    • 2
  • A. G. Grosheva
    • 1
  • P. V. Panyushkin
    • 2
  • I. L. Moskvina
    • 1
  • N. N. Vorob’eva
    • 3
  • V. N. Bagratashvili
    • 3
  1. 1.N. F. Gamaleya Research Centre of Epidemiology and MicrobiologyMinistry of Health of the Russian FederationMoscowRussia
  2. 2.I. M. Sechenov First Moscow State Medical UniversityMinistry of Health of the Russian FederationMoscowRussia
  3. 3.Institute of Photonics Technologies, Russian Academy of Sciences, Federal Research Center “Crystallography and Photonics”Russian Academy of SciencesMoscowRussia

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