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Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging

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Bulletin of Experimental Biology and Medicine Aims and scope

Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal’ age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.

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Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    A.P. Ryzhak, N. I. Chalisova, N. S. Lin’kova, N. V. Kolchina, G. A. Ryzhak & R. I. Khalimov

  2. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    N. I. Chalisova, N. S. Lin’kova, T. E. Nichik & A.V. Dudkov

  3. Peter the Great St.Petersburg Polytechnic University, St. Petersburg, Russia

    N. S. Lin’kova

Authors
  1. A.P. Ryzhak
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  2. N. I. Chalisova
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  3. N. S. Lin’kova
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  4. T. E. Nichik
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  5. A.V. Dudkov
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  6. N. V. Kolchina
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  7. G. A. Ryzhak
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  8. R. I. Khalimov
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Corresponding author

Correspondence to N. S. Lin’kova.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 221-225, October, 2016

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Ryzhak, A., Chalisova, N.I., Lin’kova, N.S. et al. Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging. Bull Exp Biol Med 162, 534–538 (2017). https://doi.org/10.1007/s10517-017-3655-8

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  • DOI: https://doi.org/10.1007/s10517-017-3655-8

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