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Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 524–527 | Cite as

Relationship between the Level of Circulating CD45+ Platelets and Development of Restenosis after Implantation of Drug-Eluting Stents to Patients with Coronary Heart Disease

  • Z. A. Gabbasov
  • S. G. Kozlov
  • S. V. Byazrova
  • I. S. Mel’nikov
  • O. S. Saburova
Article
  • 38 Downloads

The study was carried out in 126 patients with stable angina pectoris, who underwent elective coronary artery stenting with drug-eluting stents and follow-up angiography within 6-12 months thereafter. Five significant risk factors of restenosis were identified by binary comparisons of different variables. The logistic regression equation that included the level of CD45-positive platelets, diabetes, small vessel stenting, number of simultaneously implanted stents in one patient, and lesion length demonstrates the highest level of prediction of in-stent restenosis (OR=22.8; p<0.001). ROC-analysis demonstrated high prognostic value of the logit model (area under ROC curve 0.87, p<0.001). The data suggest that a close relationship exists between the development of restenosis and the level of circulating CD45+ platelets.

Key Words

coronary heart disease drug-eluting stents CD45+platelets restenosis 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Z. A. Gabbasov
    • 1
  • S. G. Kozlov
    • 1
  • S. V. Byazrova
    • 1
  • I. S. Mel’nikov
    • 1
  • O. S. Saburova
    • 1
  1. 1.Russian Cardiology Research and Production ComplexMinistry of Health of the Russian FederationMoscowRussia

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