Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 520–523 | Cite as

Systemic Amyloidosis Model on Young Mice

  • V. A. Kozlov
  • S. P. Sapozhnikov
  • P. B. Karyshev
  • A. I. Sheptukhina
  • O. V. Nikolaeva

Subcutaneous daily injection (with neglect of aseptics) of 0.5 ml solution of soybean cream substitute (10% volume in distilled water) during 30 days caused systemic amyloidosis in 30-day-old mice. All the known methods for induction of systemic amyloidosis are based on the use of old animals, as senile tissue bradytrophy allows effective simulation of amyloidosis.

Key Words

amyloidosis model young mice 


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • V. A. Kozlov
    • 1
  • S. P. Sapozhnikov
    • 1
  • P. B. Karyshev
    • 2
  • A. I. Sheptukhina
    • 1
  • O. V. Nikolaeva
    • 1
  1. 1.Department of Medical Biology with a Course of Microbiology and VirologyCheboksaryRussia
  2. 2.Department of Common, Clinical Pathology and Forensic MedicineI. N. Ulyanov Chuvash State UniversityCheboksaryRussia

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