Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 479–482 | Cite as

The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy

  • O. V. Kazakov
  • A. V. Kabakov
  • I. Yu. Ishchenko
  • A. F. Poveshchenko
  • T. V. Raiter
  • D. N. Strunkin
  • S. V. Michurina
  • V. I. Konenkov
ONCOLOGY

Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out. The area of the cortical matter in the thymus decreased 6 months after carcinogenesis induction, the percentage of connective tissue elements and glandular tissue and the counts of immunoblasts and cells with pyknotic nuclei increased, this indicating the development of accidental involution of the thymus. Animals of the experimental tumor+chemotherapy group exhibited morphological signs of lymphocyte migration from the thymus and suppressed activities of the lymphoid and epithelial components (lesser area of connective tissue elements and glandular tissue, lesser density of parenchymatous cell elements, lesser counts of immunoblasts and small lymphocytes, and larger area of the medulla) in comparison with animals without chemotherapy.

Key Words

thymus mammary tumor lymphocytes 

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References

  1. 1.
    Volkova MS, Astashov VV, Kazakov OV, Larionov PM, Chepik VI. Investigation of lymph nodes at experimental cancerogenesis of mammary gland. Vestn Novosibirsk. Gos. Univer. Ser.: Biol., Klin. Meditsina. 2011;9(1):152-158. Russian.Google Scholar
  2. 2.
    Drandrova EG, Struchko GYu, Merkulova LM, Kostrova OYu, Moskvichev EV, Mikhaylova MN, Arlashkina OM. Immunohistochemical researches of thymic cellular composition at carcinogenesis in condition of congenital immunodeficiency. Sovr. Probl. Obrazov. 2015;(3):193. Russian.Google Scholar
  3. 3.
    Kazakov OV, Kabakov AV, Poveschenko AF, Miller TV, Chepik VI, Rajter TV, Strunkin DN, Larionov PM, Konenkov VI. Thymus in mammary gland experimental carcinogenesis. Vestn. Novosibirs. Gos. Univer. Ser.: Biol., Klin. Meditsina. 2014;12(3):58-62. Russian.Google Scholar
  4. 4.
    Kiseleva EP. Mechanisms of thymic involution in tumor growth. Uspekhi Sovrem. Biol. 2004;124(6):589-601. Russian.Google Scholar
  5. 5.
    Koveshnikov VG, Bibik EYu. Functional Morphology of the Immune System Organs. Lugansk, 2007. Russian.Google Scholar
  6. 6.
    Sarkisov DS, Perov YuL. Microscopic Technique. Moscow, 1996. Russian.Google Scholar
  7. 7.
    Cheknev SB. Natural cytotoxicity in the complex cellular interactions. Vestn. Ross. Med. Akad. Nauk. 1999;(4):30-34. Russian.Google Scholar
  8. 8.
    Chernushenko EF. Diagnosis of secondary immunodeficiencies. Zh. Such. Lekarya. Mistets. Likuvan. 2006;(2):5-12. Russian.Google Scholar
  9. 9.
    Freyer G, Braud A.C, Chaibi P, Spielmann M, Martin JP, Vilela G, Guerin D, Zelek L. Dealing with metastatic breast cancer in elderly women: results from a French study on a large cohort carried out by the ‘Observatory on Elderly Patients’. Ann. Oncol. 2006;17(2):211-216.CrossRefPubMedGoogle Scholar
  10. 10.
    Lopez DM, Charyulu V, Adkins B. Influence of breast cancer on thymic function in mice. J. Mammary Gland Biol. Neoplasia. 2002;7(2):191-199.CrossRefPubMedGoogle Scholar
  11. 11.
    Sehbai AS, Tallaksen RJ, Bennett J, Abraham J. Thymic hyperplasia after adjuvant chemotherapy in breast cancer. Thorac. Imaging. 2006;21(1):43-46.CrossRefGoogle Scholar
  12. 12.
    Wildiers H, Kunkler I, Biganzoli L, Fracheboud J, Vlastos G, Bernard-Marty C, Hurria A, Extermann M, Girre V, Brain E, Audisio R.A, Bartelink H, Barton M, Giordano SH, Muss H, Aapro M; International Society of Geriatric Oncology. Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology. Lancet Oncol. 2007;8(12):1101-1115.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • O. V. Kazakov
    • 1
  • A. V. Kabakov
    • 1
  • I. Yu. Ishchenko
    • 1
  • A. F. Poveshchenko
    • 1
  • T. V. Raiter
    • 1
  • D. N. Strunkin
    • 1
  • S. V. Michurina
    • 1
  • V. I. Konenkov
    • 1
  1. 1.Research Institute of Clinical and Experimental LymphologyNovosibirskRussia

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