Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out. The area of the cortical matter in the thymus decreased 6 months after carcinogenesis induction, the percentage of connective tissue elements and glandular tissue and the counts of immunoblasts and cells with pyknotic nuclei increased, this indicating the development of accidental involution of the thymus. Animals of the experimental tumor+chemotherapy group exhibited morphological signs of lymphocyte migration from the thymus and suppressed activities of the lymphoid and epithelial components (lesser area of connective tissue elements and glandular tissue, lesser density of parenchymatous cell elements, lesser counts of immunoblasts and small lymphocytes, and larger area of the medulla) in comparison with animals without chemotherapy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Volkova MS, Astashov VV, Kazakov OV, Larionov PM, Chepik VI. Investigation of lymph nodes at experimental cancerogenesis of mammary gland. Vestn Novosibirsk. Gos. Univer. Ser.: Biol., Klin. Meditsina. 2011;9(1):152-158. Russian.
Drandrova EG, Struchko GYu, Merkulova LM, Kostrova OYu, Moskvichev EV, Mikhaylova MN, Arlashkina OM. Immunohistochemical researches of thymic cellular composition at carcinogenesis in condition of congenital immunodeficiency. Sovr. Probl. Obrazov. 2015;(3):193. Russian.
Kazakov OV, Kabakov AV, Poveschenko AF, Miller TV, Chepik VI, Rajter TV, Strunkin DN, Larionov PM, Konenkov VI. Thymus in mammary gland experimental carcinogenesis. Vestn. Novosibirs. Gos. Univer. Ser.: Biol., Klin. Meditsina. 2014;12(3):58-62. Russian.
Kiseleva EP. Mechanisms of thymic involution in tumor growth. Uspekhi Sovrem. Biol. 2004;124(6):589-601. Russian.
Koveshnikov VG, Bibik EYu. Functional Morphology of the Immune System Organs. Lugansk, 2007. Russian.
Sarkisov DS, Perov YuL. Microscopic Technique. Moscow, 1996. Russian.
Cheknev SB. Natural cytotoxicity in the complex cellular interactions. Vestn. Ross. Med. Akad. Nauk. 1999;(4):30-34. Russian.
Chernushenko EF. Diagnosis of secondary immunodeficiencies. Zh. Such. Lekarya. Mistets. Likuvan. 2006;(2):5-12. Russian.
Freyer G, Braud A.C, Chaibi P, Spielmann M, Martin JP, Vilela G, Guerin D, Zelek L. Dealing with metastatic breast cancer in elderly women: results from a French study on a large cohort carried out by the ‘Observatory on Elderly Patients’. Ann. Oncol. 2006;17(2):211-216.
Lopez DM, Charyulu V, Adkins B. Influence of breast cancer on thymic function in mice. J. Mammary Gland Biol. Neoplasia. 2002;7(2):191-199.
Sehbai AS, Tallaksen RJ, Bennett J, Abraham J. Thymic hyperplasia after adjuvant chemotherapy in breast cancer. Thorac. Imaging. 2006;21(1):43-46.
Wildiers H, Kunkler I, Biganzoli L, Fracheboud J, Vlastos G, Bernard-Marty C, Hurria A, Extermann M, Girre V, Brain E, Audisio R.A, Bartelink H, Barton M, Giordano SH, Muss H, Aapro M; International Society of Geriatric Oncology. Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology. Lancet Oncol. 2007;8(12):1101-1115.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 10, pp. 476-480, October, 2016
Rights and permissions
About this article
Cite this article
Kazakov, O.V., Kabakov, A.V., Ishchenko, I.Y. et al. The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy. Bull Exp Biol Med 162, 479–482 (2017). https://doi.org/10.1007/s10517-017-3644-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-017-3644-y