Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 470–473 | Cite as

Immunogenesis in White Mice Infected with Yersinia pestis with Different Plasmid Composition

  • S. V. Balakhonov
  • S. A. Vityazeva
  • V. I. Dubrovina
  • T. P. Starovoitova
  • G. B. Mukhturgin
  • T. A. Ivanova
  • K. M. Korytov
  • S. I. Kolesnikov
MICROBIOLOGY AND IMMUNOLOGY
  • 36 Downloads

Morphological changes in the immunocompetent organs of white mice with experimental plague infection manifested in activation of the immune response of different degree and pathological process of different severity that depended on the plasmid composition of Y. pestis. Widening of the T-dependent zones in the immune organs of white mice infected with isogenic strains of Y. pestis with different plasmid composition attests to activation of cellular immunity. Our findings allow considering Y. pestis subsp. altaica I-2948/3, Y. pestis subsp. pestis I-3479 and Y. pestis subsp. pestis I-3480 as promising candidates for vaccine strains.

Key Words

Yersinia pestis experimental animals plasmids immunocompetent organs 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • S. V. Balakhonov
    • 1
  • S. A. Vityazeva
    • 1
  • V. I. Dubrovina
    • 1
  • T. P. Starovoitova
    • 1
  • G. B. Mukhturgin
    • 1
  • T. A. Ivanova
    • 1
  • K. M. Korytov
    • 1
  • S. I. Kolesnikov
    • 2
  1. 1.Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human WelfareIrkutskRussia
  2. 2.Research Center of Family Health Problems and Human ReproductionIrkutskRussia

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