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Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 466–469 | Cite as

Pharmacological Analysis of the Therapeutic Effect of Radioprotectors Cystamine and Indralin in the Capacity of Radiomitigators

  • M. V. Vasin
  • I. B. Ushakov
  • V. Yu. Kovtun
  • S. N. Komarova
  • L. A. Semenova
  • A. A. Galkin
  • R. V. Afanas’ev
  • I. V. Bukhtiyarov
Article

The therapeutic radiomitigating effect of cystamine and indralin was studied in experiments on mice and rats and pharmacological analysis of these drugs was carried out. The animals were subjected to whole-body 60Co γ-irradiation. The mice were exposed to single (9-10 Gy) or double (8 Gy) irradiation with an interval of 1 month. The rats were exposed to 10 Gy with partial shielding of the upper quarter of the abdomen. In experiments on mice, pretreatment with reserpine abolished the therapeutic effect of cystamine administered repeatedly every 15 min over 1 h after irradiation. Moreover, summation of the radioprotective and therapeutic effects of the radioprotector was revealed under these conditions. In mice and rats, α1-adrenoreceptor blocker terazosin did not abolish the therapeutic effect of indralin administrated after irradiation, but blocked the radioprotective effect of indralin applied prior to irradiation. At the same time, 5-HT2 serotonin receptor blocker tropoxin abolished the therapeutic effect of indralin without affecting its radioprotective activity.

Key Words

indralin cystamine shielding tropoxin terazosin 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • M. V. Vasin
    • 1
  • I. B. Ushakov
    • 1
  • V. Yu. Kovtun
    • 2
  • S. N. Komarova
    • 1
  • L. A. Semenova
    • 1
  • A. A. Galkin
    • 1
  • R. V. Afanas’ev
    • 1
  • I. V. Bukhtiyarov
    • 1
  1. 1.Research Institute of Occupational Medicine, Russian Academy of SciencesMoscowRussia
  2. 2.Research and Development Center “Farmzaschita”, the Federal Medical-Biological Agency of RussiaKhimkiRussia

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