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Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran

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Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin activity of dextran sulfate with a molecular weight of 20 kDa reached 12.6-15.3 U/mg. Dextran sulfates with molecular weights of 20 and 150 kDa did not potentiate ADP-induced human platelet aggregation.

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Authors and Affiliations

  1. National Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia

    N. N. Drozd & Yu. S. Logvinova

  2. Institute of Chemistry, Komi Science Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia

    M. A. Torlopov & E. V. Udoratina

Authors
  1. N. N. Drozd
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  2. Yu. S. Logvinova
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  3. M. A. Torlopov
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  4. E. V. Udoratina
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Correspondence to N. N. Drozd.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 10, pp. 456-459, October, 2016

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Drozd, N.N., Logvinova, Y.S., Torlopov, M.A. et al. Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran. Bull Exp Biol Med 162, 462–465 (2017). https://doi.org/10.1007/s10517-017-3640-2

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  • DOI: https://doi.org/10.1007/s10517-017-3640-2

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