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Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 458–461 | Cite as

Effect of Successive Administration of Vancomycin and Amikacin on Auditory Function of Immature Animals

  • I. N. D’yakonova
  • O. V. Kamkina
  • I. V. Rakhmanova
  • Yu. S. Ishanova
  • D. S. Burmistrova
Article

Effect of successive administration vancomycin and amikacin in therapeutic doses on immature auditory organ was compared to single administration of the same drugs in chronic experiments on immature rabbits by recording of short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Drug administration always increased significantly the ABR peak I threshold. Ototoxic antibiotics did not change DPOAE, but selectively affected activity of outer hair cells. No enhancement of the ototoxic effects was observed after successive administration of the two antibiotics.

Key Words

vancomycin amikacin rabbits immature auditory analyzer short-latency auditory brainstem response 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • I. N. D’yakonova
    • 1
  • O. V. Kamkina
    • 1
  • I. V. Rakhmanova
    • 1
  • Yu. S. Ishanova
    • 1
  • D. S. Burmistrova
    • 1
  1. 1.N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian FederationMoscowRussia

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