Effect of Successive Administration of Vancomycin and Amikacin on Auditory Function of Immature Animals
Effect of successive administration vancomycin and amikacin in therapeutic doses on immature auditory organ was compared to single administration of the same drugs in chronic experiments on immature rabbits by recording of short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Drug administration always increased significantly the ABR peak I threshold. Ototoxic antibiotics did not change DPOAE, but selectively affected activity of outer hair cells. No enhancement of the ototoxic effects was observed after successive administration of the two antibiotics.
Key Wordsvancomycin amikacin rabbits immature auditory analyzer short-latency auditory brainstem response
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- 1.Gvelesiani TG. Afe-related changes in otoacoustic emission. Vestn. Otorinolaringol. 2003;(6):11-13. Russian.Google Scholar
- 2.Goodman and Gilman’s Pharmacological Basis of Therapeutics. Moscow, 2006. P. 943-944. Russian.Google Scholar
- 3.D’yakonova IN, Ishanova YS, Rakhmanova IV, Sapozhnikov JM, Tikhomirov A.M.1, Sergeyeva E.G.1 Effect of netilmicin on the auditory analyzer (experimental study). Pediatr. Farmakol. 2011;8(5):70-75. Russian.Google Scholar
- 6.Diakonova IN, Rakhmanova IV, Burmistrova DS, Ishanova YuS. Investigation of the influence of vancomycin on the auditory function of immature animals. Vestn. Ross. Gos. Med. Univer. 2013;(4):75-79. Russian.Google Scholar
- 8.Bhat YR, Lewis LE, K EV. Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: an audit from a center in India. Ital. J. Pediatr. 2011;37:32. doi: 10.1186/1824-7288-37-32.Google Scholar