Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 454–457 | Cite as

Dipeptide Mimetic of the Brain-derived Neurotrophic Factor Prevents Impairments of Neurogenesis in Stressed Mice

  • T. A. Gudasheva
  • P. Yu. Povarnina
  • S. B. Seredenin
Article
  • 67 Downloads

Brain-derived neurotrophic factor (BDNF) plays the central role in the mechanisms of regulation of neurogenesis and neuroplasticity. Impairment of these mechanisms is considered as one of the main etiological factors of depression. Dimeric dipeptide mimetic of BDNF loop 4 bis-(N-monosuccinyl-l-seryl-l-lysine) hexamethylenediamide (GSB-106) was synthesized at the V. V. Zakusov Research Institute of Pharmacology. In vivo experiments revealed significant antidepressant properties of GSB-106 in doses of 0.1-10 mg/kg (intraperitoneally and orally). Effects of GSB-106 on hippocampal neurogenesis were studied in mice subjected to chronic predator stress. Proliferative activity in the subgranular zone of the dental gyrus was assessed immunohistochemically by Ki-67 expression (a marker of dividing cells). It was found that GSB-106 (10 mg/kg, intraperitoneally, 5 days) completely prevents neurogenesis disturbances in stressed mice. These findings suggest that GSB-106 is a promising candidate for the development of antidepressant agents with BDNF-like mechanism of action.

Key Words

dipeptide mimetics brain-derived neurotrophic factor GCB-106 stress neurogenesis 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • T. A. Gudasheva
    • 1
  • P. Yu. Povarnina
    • 1
  • S. B. Seredenin
    • 2
  1. 1.Laboratory of Peptide BioregulatorsV. V. Zakusov Research Institute of PharmacologyMoscowRussia
  2. 2.Department of PharmacogeneticsV. V. Zakusov Research Institute of PharmacologyMoscowRussia

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