Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 445–450 | Cite as

Dependence between LD50 for Rodents and LC50 for Adult Fish and Fish Embryos

  • K. V. Zolotarev
  • N. F. Belyaeva
  • A. N. Mikhailov
  • M. V. Mikhailova
Article

We revealed empirical dependences between common logarithm of a ratio of rat oral LD50 to LCa 50 for adult fish and lgP for 50 different chemicals; and common logarithm of a ratio of the oral LD50 in rodents to LCe 50 for fish embryos and lgP for 30 different chemicals. The dependences were obtained by constructing a trend line between experimental points and calculation of Pearson’s R correlation coefficient as a measure of regression significance. These dependences can show the influence of substance lipophilicity on its toxicity for aquatic organisms comparing to mammals.

Key Words

empiric dependences LD50 for rodents LC a50 for adult fish LCe50 for fish embryos distribution coefficient lgP 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Braunbeck T, Böttcher M, Hollert H, Kosmehl T, Lammer E, Leist E, Rudolf M, Seitz N. Towards an alternative for the acute fish LC(50) test in chemical assessment: the fish embryo toxicity test goes multi-species — an update. ALTEX. 2005;22(2):87-102.Google Scholar
  2. 2.
    Calleja MC, Geladi P, Persoone G. QSAR models for predicting the acute toxicity of selected organic chemicals with diverse structures to aquatic non-vertebrates and humans. SAR QSAR Environ. Res. 1994;2(3):193-234.CrossRefPubMedGoogle Scholar
  3. 3.
    Delistraty D, Taylor B, Anderson R. Comparisons of acute toxicity of selected chemicals to rainbow trout and rats. Ecotoxicol. Environ. Saf. 1998;39(3):195-200.CrossRefPubMedGoogle Scholar
  4. 4.
    Groth G, Schreeb K, Herdt V, Freundt KJ. Toxicity studies in fer-tilized zebrafish eggs treated with N-methylamine, N,N-dimethylamine, 2-aminoethanol, isopropylamine, aniline, N-methylaniline, N,N-dimethylaniline, quinone, chloroacetaldehyde, or cyclohexanol. Bull. Environ. Contam. Toxicol. 1993;50(6):878-882.CrossRefPubMedGoogle Scholar
  5. 5.
    Kammann U, Vobach M, Wosniok W. Toxic effects of brominated indoles and phenols on zebrafish embryos. Arch. Environ. Contam. Toxicol. 2006;51(1):97-102.CrossRefPubMedGoogle Scholar
  6. 6.
    Kari G, Rodeck U, Dicker AP. Zebrafish: an emerging model system for human disease and drug discovery. Clin. Pharmacol. Ther. 2007;82(1):70-80.CrossRefPubMedGoogle Scholar
  7. 7.
    Lahnsteiner F. The sensitivity and reproducibility of the zebrafish (Danio rerio) embryo test for the screening of waste water quality and for testing the toxicity of chemicals. Altern. Lab. Anim. 2008;36(3):299-311.PubMedGoogle Scholar
  8. 8.
    Lammer E, Carr GJ, Wendler K, Rawlings JM, Belanger SE, Braunbeck T. Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test? Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2009;149(2):196-209.CrossRefPubMedGoogle Scholar
  9. 9.
    Regulation (EC) No 1907/2006 of 18 December 2006 concerning the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH). European Parliament and Council of the European Union. 2006.Google Scholar
  10. 10.
    Sukardi H, Chng HT, Chan C.Y, Gong Z, Lam SH. Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models. Expert Opin. Drug Metab. Toxicol. 2011;7(5):579-589.CrossRefPubMedGoogle Scholar
  11. 11.
    Vaughan M, van Egmond R. The use of the zebrafish (Danio rerio) embryo for the acute toxicity testing of surfactants, as a possible alternative to the acute fish test. Altern Lab. Anim. 2010;38(3):231-238.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • K. V. Zolotarev
    • 1
  • N. F. Belyaeva
    • 1
  • A. N. Mikhailov
    • 1
  • M. V. Mikhailova
    • 1
  1. 1.V. N. Orekhovich Research Institute of Biomedical ChemistryMoscowRussia

Personalised recommendations