Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 445–450 | Cite as

Dependence between LD50 for Rodents and LC50 for Adult Fish and Fish Embryos

  • K. V. Zolotarev
  • N. F. Belyaeva
  • A. N. Mikhailov
  • M. V. Mikhailova

We revealed empirical dependences between common logarithm of a ratio of rat oral LD50 to LCa 50 for adult fish and lgP for 50 different chemicals; and common logarithm of a ratio of the oral LD50 in rodents to LCe 50 for fish embryos and lgP for 30 different chemicals. The dependences were obtained by constructing a trend line between experimental points and calculation of Pearson’s R correlation coefficient as a measure of regression significance. These dependences can show the influence of substance lipophilicity on its toxicity for aquatic organisms comparing to mammals.

Key Words

empiric dependences LD50 for rodents LC a50 for adult fish LCe50 for fish embryos distribution coefficient lgP 


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • K. V. Zolotarev
    • 1
  • N. F. Belyaeva
    • 1
  • A. N. Mikhailov
    • 1
  • M. V. Mikhailova
    • 1
  1. 1.V. N. Orekhovich Research Institute of Biomedical ChemistryMoscowRussia

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