Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 436–440 | Cite as

Involvement of Glucagon-Like Peptide-1 in the Regulation of Selective Excretion of Sodium or Chloride Ions by the Kidneys

  • A. S. Marina
  • A. V. Kutina
  • E. I. Shakhmatoba
  • Yu. V. Natochin

An increase of total glucagon-like peptide-1 (GLP-1) concentration in the plasma in rats was revealed 5 min after oral, but not intraperitoneal administration of NaCl or Trizma HCl solutions. The increase in GLP-1 level was similar to that after oral glucose administration. After intraperitoneal administration of 2.5% NaCl, GLP-1 mimetic exenatide accelerated natriuresis and urinary chloride excretion. Under conditions of normonatriemia and hyperchloremia induced by injection of 6.7% Trizma HCl, exenatide stimulated chloride excretion and reabsorption of sodium ions in the kidneys. These findings suggest that GLP-1 participates in selective regulation of the balance of sodium and chloride ions.

Key Words

kidneys glucagon-like peptide-1 exenatide sodium ion excretion chloride ion excretion 


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • A. S. Marina
    • 1
  • A. V. Kutina
    • 1
  • E. I. Shakhmatoba
    • 1
  • Yu. V. Natochin
    • 1
  1. 1.I. M. Sechenov Institute of Evolutionary Physiology and BiochemistryRussian Academy of SciencesSt. PetersburgRussia

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