Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 433–435 | Cite as

Impairment of Energy-Dependent Processes in the Muscle Tissue as a Pathogenetic Mechanism of Statin-Induced Myopathy

  • Z. I. Mikashinovich
  • E. S. Belousova
  • O. G. Sarkisyan
Article
  • 79 Downloads

Administration of simvastatin was followed by a decrease in activities of superoxide dismutase and cytochrome oxidase in rat mitochondria, which attested to dysfunction of the respiratory chain. The decrease in total ATPase and Ca2+-ATPase activities in muscle tissue homogenates reflected impaired transport of active cations essential for muscle contraction. We conclude that abnormal relationships in the system of energy synthetic and energy-dependent processes in myocytes serve as the molecular basis for the formation of statin-induced degenerative changes.

Key Words

statins simvastatin skeletal muscles statin-induced myopathy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Mikashinovich ZI, Letunovskii AV, Volozhin OO, Belousova ES. Biochemical Studies of the Saliva in Clinical Practice. Mikashinovich ZI, ed. Rostov-on-Don, 2004. Russian.Google Scholar
  2. 2.
    Kryzhanovskii GN. Dysregulation Pathology. Moscow, 2002. Russian.Google Scholar
  3. 3.
    Bhardwaj S, Selvarajah S, Schneider EB. Muscular effects of statins in the elderly female: a review. Clin. Interv. Aging. 2013;8:47-59.PubMedPubMedCentralGoogle Scholar
  4. 4.
    Kumar A, Vashist A, Kumar P, Kalonia H, Mishra J. Protective effect of HMG CoA reductase inhibitors against running wheel activity induced fatigue, anxiety like behavior, oxidative stress and mitochondrial dysfunction in mice. Pharmacol. Rep. 2012;64(6):1326-1336.CrossRefPubMedGoogle Scholar
  5. 5.
    Lankin VZ, Tikhaze AK, Kukharchuk VV, Konovalova GG, Pisarenko OI, Kaminnyi AI, Shumaev KB, Belenkov YN. Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins. Mol. Cell. Biochem. 2003;249(1-2):129-140.CrossRefPubMedGoogle Scholar
  6. 6.
    Muraki A, Miyashita K, Mitsuishi M, Tamaki M, Tanaka K, Itoh H. Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance. J. Appl. Physiol. (1985). 2012;113(3):479-486.Google Scholar
  7. 7.
    Parker BA, Gregory SM, Lorson L, Polk D, White CM, Thompson PD. A randomized trial of coenzyme Q10 in patients with statin myopathy: rationale and study design. J. Clin. Lipidol. 2013;7(3):187-193.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Parker BA, Thompson PD. Effect of statins on skeletal muscle: exercise, myopathy, and muscle outcomes. Exerc. Sport Sci. Rev. 2012;40(4):188-194.PubMedPubMedCentralGoogle Scholar
  9. 9.
    Sirvent P, Fabre O, Bordenave S, Hillaire-Buys D, Raynaud De Mauverger E, Lacampagne A, Mercier J. Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins. Toxicol. Appl. Pharmacol. 2012;259(2):263-268.Google Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Z. I. Mikashinovich
    • 1
  • E. S. Belousova
    • 2
  • O. G. Sarkisyan
    • 1
  1. 1.Department of General and Clinical Biochemistry No. 1Rostov State Medical University, Ministry of Health of the Russian FederationRostov-on-DonRussia
  2. 2.Department of Pharmaceutical Chemistry and PharmacognosyRostov State Medical University, Ministry of Health of the Russian FederationRostov-on-DonRussia

Personalised recommendations