Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 430–432 | Cite as

Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice

  • M. A. Gruden
  • T. V. Davydova
  • V. G. Fomina
  • L. A. Vetrile
  • L. A. Morozova-Roche
  • R. D. E. Sewell

Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.

Key Words

amnesia S100A9 fibrils antibodies to glutamate spatial memory locomotor activity 


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • M. A. Gruden
    • 1
  • T. V. Davydova
    • 2
  • V. G. Fomina
    • 2
  • L. A. Vetrile
    • 2
  • L. A. Morozova-Roche
    • 3
  • R. D. E. Sewell
    • 4
  1. 1.P. K. Anokhin Research Institute of Normal PhysiologyMoscowRussia
  2. 2.Research Institute of General Pathology and PathophysiologyMoscowRussia
  3. 3.Department of Medical Biochemistry and BiophysicsUmea UniversityUmeaSweden
  4. 4.Cardiff School of Pharmacy and Pharmaceutical SciencesCardiff UniversityCardiffUK

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