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Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 425–429 | Cite as

MRI Study for the Features of Brain Conduction Pathways in Patients with an Ultra-High Risk of Endogenous Psychoses

  • A. S. Tomyshev
  • I. S. Lebedeva
  • T. A. Akhadov
  • M. A. Omel’chenko
  • M. V. Ublinskii
  • N. A. Semenova
  • V. G. Kaleda
Article

Diffusion parameters of brain tracts (n=18) were studied in 27 men with ultra-high risk of endogenous attack-like psychoses and 27 mentally healthy men of the same age group (fractional anisotropy; and average, radial, and axial diffusion). Correlation analysis was performed between these parameters and severity of mental disorders (SOPS scale). The indexes of radial diffusion and axial diffusion were shown to change in the left anterior thalamic radiation and right posterior cingulum bundle, respectively. Our results are consistent with published data that disturbances in the frontal and temporal lobes play an important role in the pathogenesis of schizophrenia. The degree of mental disorders correlated with diffusion parameters in the left and right anterior cingulum bundle.

Key Words

ultra-high risk schizophrenia magnetic resonance imaging (MRI) tractography frontal lobes 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • A. S. Tomyshev
    • 1
  • I. S. Lebedeva
    • 1
  • T. A. Akhadov
    • 2
  • M. A. Omel’chenko
    • 1
  • M. V. Ublinskii
    • 2
    • 3
  • N. A. Semenova
    • 2
    • 3
    • 4
  • V. G. Kaleda
    • 1
  1. 1.Mental Health Research CenterMoscowRussia
  2. 2.Emergency Children’s Surgery and Traumatology Research InstituteMoscowRussia
  3. 3.N. M. Emanuel Institute of Biochemical PhysicsMoscowRussia
  4. 4.N. N. Semenov Institute of Chemical PhysicsMoscowRussia

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