Two groups of breast cancer patients (53 ± 2 years) in clinical remission receiving no specific therapy were examined: group 1, with BRCA1 gene mutations (N = 11) and group 2, without mutations of this kind (N = 11). The two groups did not differ by insulinemia and glycemia, insulin resistance index, blood levels of thyrotropic hormone, sex hormone-binding globulin, insulin-like growth factor-1, triglycerides, or lipoproteins. In group 1, blood estradiol level was higher. Intensive glucose-induced generation of reactive oxygen species in these patients was associated with a decrease of cholesterolemia, of the C-peptide/insulin proportion, and a trend to higher urinary excretion of 4-hydroxyestrone, one of the most genotoxic catecholestrogens. BRCA1 gene mutations in breast cancer patients were associated with signs of estrogenization and a pro-genotoxic shift in the estrogen and glucose system, which could modulate the disease course and requires correction.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 11, pp. 541-544, November, 2011
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Berstein, L.M., Boyarkina, M.P., Vasilyev, D.A. et al. Endocrine Metabolic Disorders in Patients with Breast Cancer, Carriers of BRCA1 Gene Mutations. Bull Exp Biol Med 152, 610–612 (2012). https://doi.org/10.1007/s10517-012-1588-9
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DOI: https://doi.org/10.1007/s10517-012-1588-9