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Dying to communicate: apoptotic functions of Eph/Ephrin proteins

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A Correction to this article was published on 04 July 2018

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Abstract

The Erythropoietin-producing human hepatocellular carcinoma (Eph) receptors constitute the largest family of receptor tyrosine kinases and interact with a group of ligands called Ephrins. An essential feature of the Eph receptors and Ephrin ligands is that both are membrane-bound and, upon cell–cell interaction, initiate a bidirectional signaling involving both the receptor (forward signaling) and the ligand (reverse signaling). They regulate a large set of pleiotropic functions in virtually every tissue and physiological system. In vitro as well as in vivo data support a role for Eph and Ephrin molecules in cellular processes such as proliferation, cell–cell attraction and repulsion, motility and sorting. An increasing amount of evidence supports a role for these molecules in apoptosis and, although this function in cell death has been barely examined, the available information warrants a global consideration, to identify unmet needs and potential research avenues. Here we propose a comprehensive analysis of the data available regarding the importance of Ephs and Ephrins in cell death mechanisms throughout a large array of physiological systems.

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Change history

  • 04 July 2018

    The original version of this article contained a mistake in reference. The references in Table 1 are incorrect. The corrected Table with proper citation is given below. The field codes ADDIN REFMGR.CITE inadvertently appeared along the article. This was overlooked during the process.

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  1. Department of Pathology, Wayne State University School of Medicine, Scott Hall Bldg. Room 9207, 540 East Canfield, Detroit, MI, 48201, USA

    Mustapha Kandouz

  2. Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA

    Mustapha Kandouz

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Kandouz, M. Dying to communicate: apoptotic functions of Eph/Ephrin proteins. Apoptosis 23, 265–289 (2018). https://doi.org/10.1007/s10495-018-1458-7

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