Interplay between carbon, nitrogen and phosphate utilization in the control of secondary metabolite production in Streptomyces
Streptomyces species are a wide and diverse source of many therapeutic agents (antimicrobials, antineoplastic and antioxidants, to name a few) and represent an important source of compounds with potential applications in medicine. The effect of nitrogen, phosphate and carbon on the production of secondary metabolites has long been observed, but it was not until recently that the molecular mechanisms on which these effects rely were ascertained. In addition to the specific macronutrient regulatory mechanisms, there is a complex network of interactions between these mechanisms influencing secondary metabolism. In this article, we review the recent advances in our understanding of the molecular mechanisms of regulation exerted by nitrogen, phosphate and carbon sources, as well as the effects of their interconnections, on the synthesis of secondary metabolites by members of the genus Streptomyces.
KeywordsSecondary metabolism Antibiotic production Carbon regulation Regulation Streptomyces
This work was supported by Grant CB-219686 from Consejo Nacional de Ciencia y Tecnología, Mexico.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving human participants or animals
This article does not contain any studies with animals performed by any of the authors.
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