Pre-exposure prophylaxis is effective in preventing HIV, but data show that its effectiveness is compromised by suboptimal adherence. This randomized controlled trial (n = 69) tested the impact of an iPhone game, Viral Combat, on PrEP adherence over 24 weeks. Tenofovir-diphosphate in red blood cells was collected as a biological outcome of adherence. At 24-weeks, intervention participants were 3.75 (95% CI: 1.20–11.77; p = 0.02) times as likely to engage in optimal PrEP dosing compared to controls. Viral Combat showed preliminary efficacy in improving PrEP adherence for diverse young men who have sex with men.
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This publication was made possible with help from the Providence-Boston Center for AIDS Research (P30 AI 042853) and support from grant number R34MH104068 (MPI: LW, LKB) from the National Institute of Child Health and Human Development.
Conflict of interest
LM has received honoraria for advisory boards and speaker bureau participation from Gilead Sciences, ViiV Healthcare, and Merck, and his institution has received grants from these companies.
Procedures were in accordance with ethical standards for human subjects research. All participants provided informed, written consent.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Whiteley, L., Craker, L., Haubrick, K.K. et al. The Impact of a Mobile Gaming Intervention to Increase Adherence to Pre-exposure Prophylaxis. AIDS Behav (2021). https://doi.org/10.1007/s10461-020-03118-3
- Pre-exposure prophylaxis (PrEP)
- Men who have sex with men (MSM)
- Mobile technology intervention