AIDS and Behavior

, Volume 22, Issue 4, pp 1158–1164 | Cite as

MSM at Highest Risk for HIV Acquisition Express Greatest Interest and Preference for Injectable Antiretroviral PrEP Compared to Daily, Oral Medication

  • Katie B. Biello
  • Matthew J. Mimiaga
  • Christopher M. Santostefano
  • David S. Novak
  • Kenneth H. Mayer
Original Paper


Men who have sex with men (MSM) account for nearly 70% of new HIV diagnoses, with young black MSM at the highest risk for infection in the United States. Pre-exposure prophylaxis (PrEP) can decrease HIV acquisition in at-risk individuals by over 90%. However, therapeutic efficacy requires a daily pill, posing adherence challenges. Experimental modalities, including injectable PrEP given once every 2 months, may improve adherence among those most in need. To assess interest in and preference for injectable PrEP, an online survey was mounted on two popular MSM sexual networking apps. Differences by age, race, and other characteristics were examined using multinomial logistic regressions. Of 4638 respondents, 73% expressed interest in injectable PrEP and 47% indicated they would prefer an injection (compared to 17% who prefer a daily pill and 36% who were unsure). Within this sample, interest in and preference for injectable PrEP was highest among MSM at highest risk for HIV infection (i.e., younger age groups, racial/ethnic minorities, those with risker sexual behavior). As a result, if proven effective in clinical trials, injectable PrEP has the potential to reduce social disparities in HIV transmission among MSM.


HIV transmission Men who have sex with men Youth Racial/ethnic minorities Pre-exposure prophylaxis 



The authors wish to acknowledge the altruism of the participants and the assistance of the staff of Online Buddies, Inc. in mounting this web survey. This study was supported by an unrestricted research grant from ViiV Healthcare.


This study was supported by ViiV Healthcare, Inc. Additional support for Dr. Kenneth H. Mayer’s role was provided by the Harvard University Center for AIDS Research (CFAR), an NIH funded program (Grant Number P30 AI060354), which is supported by the following NIH Co-Funding and Participating Institutes and Centers: NIAID, NCI, NICHD, NHLBI, NIDA, NIMH, NIA, NIDDK, NIGMS, NIMHD, FIC, and OAR. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Compliance with Ethical Standards

Conflicts of interest

Dr. Kenneth H. Mayer has received unrestricted research grants from ViiV Healthcare, Inc. and Gilead Sciences. The remaining authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed Consent

Informed consent was obtained electronically from all individual participants included in the study. A waiver of documentation of consent was approved by the Fenway Health Institutional Review Board.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Katie B. Biello
    • 1
    • 2
    • 3
  • Matthew J. Mimiaga
    • 1
    • 2
    • 3
  • Christopher M. Santostefano
    • 2
  • David S. Novak
    • 4
  • Kenneth H. Mayer
    • 3
    • 5
    • 6
  1. 1.Departments of Behavioral & Social Sciences and EpidemiologyBrown University School of Public HealthProvidenceUSA
  2. 2.Center for Health Equity ResearchBrown University School of Public HealthProvidenceUSA
  3. 3.Fenway HealthFenway InstituteBostonUSA
  4. 4.Online Buddies, Inc.CambridgeUSA
  5. 5.Division of Infectious DiseasesHarvard Medical School/Beth Israel Deaconess Medical CenterBostonUSA
  6. 6.Global Health and PopulationHarvard T. H. Chan School of Public HealthBostonUSA

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