AIDS and Behavior

, Volume 22, Issue 6, pp 1766–1774 | Cite as

Infant Development and Pre- and Post-partum Depression in Rural South African HIV-Infected Women

  • Violeta J. Rodriguez
  • Gladys Matseke
  • Ryan Cook
  • Seanna Bellinger
  • Stephen M. Weiss
  • Maria L. Alcaide
  • Karl Peltzer
  • Doyle Patton
  • Maria Lopez
  • Deborah L. Jones
Original Paper

Abstract

HIV-exposed infants born to depressed women may be at risk for adverse developmental outcomes. Half of HIV-infected women in rural South Africa (SA) may suffer from pregnancy-related depression. This pilot study examined the impact of depression in HIV-infected women in rural SA on infant development. Mother-infant dyads (N = 69) were recruited in rural SA. Demographics, HIV disclosure, depression, male involvement, and alcohol use at baseline (18.35 ± 5.47 weeks gestation) were assessed. Male involvement, depression, infant HIV serostatus and development were assessed 12 months postnatally. Half of the women (age = 29 ± 5) reported depression prenatally and one-third reported depression postnatally. In multivariable logistic regression, not cohabiting with their male partner, nondisclosure of HIV status, and postnatal depression predicted cognitive delay; decreased prenatal male involvement predicted delayed gross motor development (ps < 0.05). Assessing pregnancy-related depression among HIV-infected women and infant development and increasing male involvement may reduce negative developmental outcomes among HIV-exposed or infected infants.

Keywords

Women Infant development HIV Depression South Africa 

Resumen

Los bebés expuestos al VIH, provenientes de mujeres deprimidas, pueden estar a riesgo de resultados adversos en el desarrollo. La mitad de las mujeres infectadas con VIH, en Sudáfrica (SA) rural, pueden sufrir de depresión relacionada con el embarazo. Este estudio piloto examinó el impacto de la depresión en el desarrollo infantil entre mujeres infectadas con VIH en SA rural. Parejas (N = 69) de madre e infante fueron reclutadas en SA rural. Se evaluaron datos demográficos, revelación de estatus de VIH a su pareja masculina, depresión, participación masculina en el embarazo y consumo de alcohol al inicio del estudio (18,35 ± 5,47 semanas de gestación). La participación masculina, depresión, el estatus serológico de VIH y el desarrollo infantil se evaluaron 12 meses postnatalmente. La mitad de las mujeres (edad = 29 ± 5) presentaron depresión prenatal y un tercio depresión postparto. En regresión logística multivariable, no vivir con su pareja, no revelar su estatus de VIH, y depresión postnatal predijeron retraso cognitivo; la disminución de participación masculina durante el embarazo predijo el desarrollo motor grueso retardado (p < 0,05). Evaluar la depresión relacionada con el embarazo entre mujeres infectadas con VIH y el desarrollo infantil; así, como aumentar la participación de las parejas masculinas pudieran reducir los resultados adversos en el desarrollo de niños expuestos a, o infectados por, el VIH.

Palabras Clave

Mujeres Desarrollo infantil VIH Depresión Sudáfrica 

Notes

Acknowledgements

This study was funded by a collaborative NIH/PEPFAR grant, R01HD078187-S. Activities were conducted with the support of the University of Miami Miller School of Medicine Center for AIDS Research, funded by an NIH grant, P30AI073961.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Violeta J. Rodriguez
    • 1
    • 2
  • Gladys Matseke
    • 3
  • Ryan Cook
    • 1
    • 4
  • Seanna Bellinger
    • 5
    • 6
  • Stephen M. Weiss
    • 1
  • Maria L. Alcaide
    • 7
  • Karl Peltzer
    • 3
    • 8
  • Doyle Patton
    • 1
  • Maria Lopez
    • 1
  • Deborah L. Jones
    • 1
  1. 1.Department of Psychiatry and Behavioral SciencesUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.Department of PsychologyUniversity of GeorgiaAthensUSA
  3. 3.HIV/AIDS/STIs and TB (HAST) Research ProgrammeHuman Sciences Research CouncilPretoriaSouth Africa
  4. 4.Department of Epidemiology, Fielding School of Public HealthUniversity of CaliforniaLos AngelesUSA
  5. 5.Department of PsychologyFlorida Atlantic UniversityBoca RatonUSA
  6. 6.Department of PsychologyFlorida International UniversityMiamiUSA
  7. 7.Division of Infectious Diseases, Department of MedicineUniversity of Miami Miller School of MedicineMiamiUSA
  8. 8.Department of Research & InnovationUniversity of LimpopoSovengaSouth Africa

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