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Interest in Long-Acting Injectable PrEP in a Cohort of Men Who have Sex with Men in China

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Abstract

Long-acting injectable (LAI) formulations of antiretrovirals (ARVs) as pre-exposure prophylaxis (PrEP) could be an attractive alternative for men who have sex with men (MSM) who are interested in ARV-based biomedical prevention but will not use a daily pill. This study investigated interest in LAI-PrEP in a cohort of MSM in China and characterized how MSM willing to use only injectable PrEP differed from MSM who would use PrEP regardless of modality or not at all. Demographic, behavioral, and risk perception measures were collected and associations investigated. A licensed LAI-PrEP agent would increase the proportion interested in PrEP by 24.5% over oral PrEP alone. Combining interest in oral and injectable PrEP, 78.5% of the sample could be covered if reported interest in PrEP translated into actual uptake. Partnership factors differentiated those who would be willing to use only LAI-PrEP versus any PrEP modality, while higher self-perception of risk was associated with interest in LAI-PrEP versus no PrEP. The addition of a second PrEP modality could yield increased population coverage of PrEP. Social and behavioral research should be undertaken in parallel with clinical development of injectable PrEP agents to identify characteristics of those who are not interested in oral PrEP but would take advantage of ARV-based prevention with the introduction of an injectable product.

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Acknowledgements

Contributions from Dr. Meyers, Ms. Wu, Mr. Qian, were supported by the China AIDS Initiative under the leadership of Dr. David Ho. Dr. Meyers was also supported by Grant # UL1TR001866 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program. Dr. Sandfort’s contribution was supported by NIMH center Grant P30-MH43520 (P.I.: Robert Remien, PhD) to HIV Center for Clinical and Behavioral Research. The contribution of Drs. Shang, Xu, and Zhang were supported by the Mega-Projects of National Science Research for the 12th Five-Year Plan (2012ZX10001-006); they thank Dr. Yongjun Jiang for support. Dr. Glidden’s contributions were supported by Grant #s R03 AI120819 and R03 AI122908.

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Authors and Affiliations

  1. Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA

    Kathrine Meyers, Yumeng Wu & Haoyu Qian

  2. HIV Center for Clinical and Behavioral Studies, Columbia University, New York, NY, USA

    Theodorus Sandfort

  3. Center for Infectious Diseases, Beijing You’an Hospital, Capital Medical University, Beijing, China

    Xiaojie Huang, Wei Xia & Hao Wu

  4. Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China

    Junjie Xu, Jing Zhang & Hong Shang

  5. University of California, San Francisco, CA, USA

    David Glidden

  6. Aaron Diamond AIDS Research Center, 455 First Avenue, Floor 7, New York, NY, 10016, USA

    Kathrine Meyers

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  1. Kathrine Meyers
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  2. Yumeng Wu
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  3. Haoyu Qian
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  10. Hao Wu
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Correspondence to Hao Wu or Hong Shang.

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Meyers, K., Wu, Y., Qian, H. et al. Interest in Long-Acting Injectable PrEP in a Cohort of Men Who have Sex with Men in China. AIDS Behav 22, 1217–1227 (2018). https://doi.org/10.1007/s10461-017-1845-z

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