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A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium

  • State-of-the-Art Modeling and Simulation of the Brain's Response to Mechanical Loads
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Abstract

We employ an advanced 3D computational model of the head with high anatomical fidelity, together with measured tissue properties, to assess the consequences of dynamic loading to the head in two distinct modes: head rotation and head extension. We use a subject-specific computational head model, using the material point method, built from T1 magnetic resonance images, and considering the anisotropic properties of the white matter which can predict strains in the brain under large rotational accelerations. The material model now includes the shear anisotropy of the white matter. We validate the model under head rotation and head extension motions using live human data, and advance a prior version of the model to include biofidelic falx and tentorium. We then examine the consequences of incorporating the falx and tentorium in terms of the predictions from the computational head model.

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Acknowledgments

Funding was this research was provided by NIH Grant NS055951 from the National Institute of Neurological Disorders and Stroke. This work was partially supported by the Department of Defense in the Center for Neuroscience and Regenerative Medicine (CNRM), and by the Intramural Research Program of the Clinical Center of the National Institutes of Health. Discussions with Fatma Madouh and Amy Dagro are greatly appreciated.

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Authors and Affiliations

  1. Hopkins Extreme Materials Institute, Johns Hopkins University, Baltimore, MD, USA

    Y.-C. Lu, N. P. Daphalapurkar & K. T. Ramesh

  2. Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA

    N. P. Daphalapurkar & K. T. Ramesh

  3. Department of Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD, USA

    J. Glaister & J. L. Prince

  4. Department of Mechanical Engineering, Washington University in St. Louis, St. Louis, MO, USA

    P. V. Bayly

  5. Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA

    A. K. Knutsen & D. L. Pham

  6. National Institutes of Health Clinical Center, Bethesda, MD, USA

    J. A. Butman

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  1. Y.-C. Lu
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Correspondence to K. T. Ramesh.

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Lu, YC., Daphalapurkar, N.P., Knutsen, A.K. et al. A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium. Ann Biomed Eng 47, 1923–1940 (2019). https://doi.org/10.1007/s10439-019-02226-z

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