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The Influence of Mineralization on Intratrabecular Stress and Strain Distribution in Developing Trabecular Bone

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Abstract

The load-transfer pathway in trabecular bone is largely determined by its architecture. However, the influence of variations in mineralization is not known. The goal of this study was to examine the influence of inhomogeneously distributed degrees of mineralization (DMB) on intratrabecular stresses and strains. Cubic mandibular condylar bone specimens from fetal and newborn pigs were used. Finite element models were constructed, in which the element tissue moduli were scaled to the local DMB. Disregarding the observed distribution of mineralization was associated with an overestimation of average equivalent strain and underestimation of von Mises equivalent stress. From the surface of trabecular elements towards their core the strain decreased irrespective of tissue stiffness distribution. This indicates that the trabecular elements were bent during the compression experiment. Inhomogeneously distributed tissue stiffness resulted in a low stress at the surface that increased towards the core. In contrast, disregarding this tissue stiffness distribution resulted in high stress at the surface which decreased towards the core. It was concluded that the increased DMB, together with concurring alterations in architecture, during development leads to a structure which is able to resist increasing loads without an increase in average deformation, which may lead to damage.

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Acknowledgements

Appreciation goes out to Bert van Rietbergen from the Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, for his assistance with the inhomogeneous finite element models. The authors would also like to thank Geerling Langenbach for critically reading the manuscript. This research was institutionally supported by the Inter-University Research School of Dentistry, through the Academic Centre for Dentistry Amsterdam.

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Authors and Affiliations

  1. Department of Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), Universiteit van Amsterdam and Vrije Universiteit, Meibergdreef 15, Amsterdam, 1105 AZ, The Netherlands

    Lars Mulder, Leo J. van Ruijven, Jan Harm Koolstra & Theo M. G. J. van Eijden

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  1. Lars Mulder
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  2. Leo J. van Ruijven
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  3. Jan Harm Koolstra
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  4. Theo M. G. J. van Eijden
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Correspondence to Lars Mulder.

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Mulder, L., van Ruijven, L., Koolstra, J. et al. The Influence of Mineralization on Intratrabecular Stress and Strain Distribution in Developing Trabecular Bone. Ann Biomed Eng 35, 1668–1677 (2007). https://doi.org/10.1007/s10439-007-9345-3

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  • DOI: https://doi.org/10.1007/s10439-007-9345-3

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