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Two-dimensional model of vesicle adhesion on curved substrates

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Abstract

We develop a two dimensional model of a vesicle adhered on a curved substrate via long-range molecular interactions while subjected to a detachment force. The relationship between the force and displacement of the vesicle is investigated as a function of the substrate shape. It is shown that both the force– displacement relationship and the maximum force at pull-off are significantly dependent on the substrate shape. The results suggest that probes with different tip shapes may be designed for cell manipulation. For example, we demonstrate that a vesicle can be pulled off a flat surface using a probe with a curved tip.

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Authors and Affiliations

  1. Department of Engineering Mechanics, Tsinghua University, Beijing, 100084, China

    Wendong Shi & Xi Qiao Feng

  2. Division of Engineering, Brown University, 182 Hope Street, Providence, RI, 02912, USA

    Wendong Shi & Huajian Gao

Authors
  1. Wendong Shi
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  2. Xi Qiao Feng
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  3. Huajian Gao
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Corresponding authors

Correspondence to Xi Qiao Feng or Huajian Gao.

Additional information

The project supported by the National Natural Science Foundation of China (10525210 and 10121202) and the 973 Program.

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Shi, W., Feng, X.Q. & Gao, H. Two-dimensional model of vesicle adhesion on curved substrates. Acta Mech Sin 22, 529–535 (2006). https://doi.org/10.1007/s10409-006-0036-3

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  • DOI: https://doi.org/10.1007/s10409-006-0036-3

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