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No more bonding, no more clamping, magnetically assisted membrane integration in microfluidic devices

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Abstract

The integration of porous membranes with microfluidic devices allows a simple but high-throughput mass transport control for numerous microfluidic applications, such as single-cell separation, sample analysis, and purification. In this study, we demonstrate a novel integration process of porous membranes into microfluidic devices by applying a magnetic field and hydrodynamically stabilizing them. This new approach simplifies the integration process by removing physicochemical bonding between membranes and microfluidic devices, but overcomes many practical issues observed in current methods, such as device leakage, membrane replacement, and membrane material selection. More importantly, our approach allows us to install membranes with diverse physicochemical features and spatial configurations into a single microfluidic device. This additional ability can significantly improve its performance and capability in applications. Finally, we successfully demonstrate the utilization of our membrane device for simple particle separation.

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Acknowledgements

The authors acknowledge the Natural Sciences and Engineering Research Council of Canada (Discovery Grant RGPIN-2017-04489) and Canada Research Chairs for supporting this research.

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Authors and Affiliations

  1. Department of Chemical Engineering, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada

    Seungyoon Han & Dae Kun Hwang

  2. Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada

    Seungyoon Han & Dae Kun Hwang

  3. Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael’s Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada

    Seungyoon Han & Dae Kun Hwang

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  1. Seungyoon Han
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  2. Dae Kun Hwang
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Correspondence to Dae Kun Hwang.

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Han, S., Hwang, D.K. No more bonding, no more clamping, magnetically assisted membrane integration in microfluidic devices. Microfluid Nanofluid 22, 107 (2018). https://doi.org/10.1007/s10404-018-2127-4

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  • DOI: https://doi.org/10.1007/s10404-018-2127-4

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