Application of polydopamine in biomedical microfluidic devices
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Polydopamine (PDA) is a bioinspired material with tremendous potential for applications involving surface modifications. By simply immersing the substrate in the dopamine monomer solution, we are able to apply a hydrophilic and biofunctional PDA coating that adheres strongly to any surface, including (super)hydrophobic surface, with unprecedented ease. Using PDA, almost any materials can be immobilized on the surface in a single step by mixing them with the dopamine monomer solution. This review provides a comprehensive coverage of the applications of PDA in the device fabrication, surface modification, and biofunctionalization of biomedical microfluidic devices. While discussing the advantages and limitations of PDA, we pay special attention to its unique properties that specifically benefit biomedical microfluidic devices. We also discuss other potential applications of PDA beyond the current development. Through this review, we hope to promote PDA and encourage a broader adoption of PDA by the microfluidic community.
KeywordsPolydopamine Biomedical Microfluidic Surface modification Surface functionalization
The authors would like to thank the start-up grant from the School of Mechanical and Aerospace Engineering at Nanyang Technological University. This work is also supported by the Ageing Research Institute for Society and Education (ARISE), Nanyang Technological University, Singapore (Grant Reference Number ARISE/2017/22), and Singapore Ministry of Education AcRF Tier 1 Grant RG49/17.
- Gomez FA (2008) Biological applications of microfluidics. Wiley, HobokenGoogle Scholar
- Ho CC, Ding SJ (2013) The pH-controlled nanoparticles size of polydopamine for anti-cancer drug delivery. J Mater Sci 24:2381–2390Google Scholar
- Lu YW, Lin PT, Pai CS (2007) Polydimethylsiloxane (PDMS) bonding strength characterization by a line force model in blister tests. Paper presented at the transducers 2007–2007 international solid-state sensors, actuators and microsystems conference, 10–14 June 2007Google Scholar
- Salazar P, Martín M, Gonzalez-Mora JL (2016) Polydopamine-modified surfaces in biosensor applications. In: Méndez-Vilas A, Solano A (eds) Polymer science: research advances, practical applications and educational aspects. Formatex Research Center, pp 385–396Google Scholar
- Zhang Y, Geng X, Ai J, Gao Q, Qi H, Zhang C (2015) Signal amplification detection of DNA using a sensor fabricated by one-step covalent immobilization of amino-terminated probe DNA onto the polydopamine-modified screen-printed carbon electrode. Sens Actuators B Chem 221:1535–1541CrossRefGoogle Scholar