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Association of left ventricular myocardial dysfunction with diabetic polyneuropathy

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Abstract

Background

The pathogenesis of left ventricular (LV) dysfunction in diabetes has been attracting attention. It has been reported that LV longitudinal systolic myocardial function determined by speckle tracking echocardiography (STE) is associated with diabetic polyneuropathy (DPN). However, the relationship between the severity of peripheral neuropathy and LV myocardial dysfunction is unknown. This study examined the relationship between the severity of DPN and echocardiographic parameters as well as clinical features.

Methods

The subjects were 166 patients (57 ± 14 years old) with diabetes who had a normal LV ejection fraction (≥ 55%). To assess LV longitudinal systolic function, global longitudinal strain (GLS) was calculated by two-dimensional STE as the average peak strain of 18 LV segments in three standard apical views. A nerve conduction study (NCS) was performed in each subject to assess the severity of neuropathy based on the NCS Baba Classification (Grade 0: no apparent abnormalities–Grade IV: abolition). Three nerves in the lower extremity were examined: tibial nerve (F-wave latency, motor nerve conduction velocity, and amplitude), sural nerve (sensory conduction velocity and amplitude), and peroneal nerve (motor nerve conduction velocity and amplitude).

Results

Of the 166 subjects, 112 subjects (67.5%) were confirmed to have DPN, and all the subjects were divided into two groups according to the presence/absence of DPN. When multivariate analysis was performed using significant factors from univariate logistic regression analysis as explanatory variables, GLS was found to be an independent determinant of DPN (odds ratio: 0.55, p < 0.001). In multivariate analysis of NCS data, F-wave latency was the most important determinant of DPN (odds ratio: 1.43, p < 0.001). There was a significant negative correlation between F-wave latency and GLS (r = − 0.43, p < 0.001). Regarding the relation between GLS and the severity of DPN, GLS was significantly lower in patients with Grade I or higher DPN than in patients without DPN, but showed no significant difference between the grades of neuropathy. In addition, GLS was significantly lower when 2–3 lower extremity nerves were affected by DPN than in patients without DPN.

Conclusion

Patients with diabetes may already have subclinical LV myocardial dysfunction when DPN is Grade I. Assessment of LV longitudinal systolic function by GLS may be important in diabetic patients with DPN.

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Acknowledgements

The authors thank Kunio Sugiyama and the staff of the neurophysiological laboratory at Toho University Medical Center Omori Hospital.

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Authors and Affiliations

  1. Department of Clinical Functional Physiology, Toho University Medical Center Omori Hospital, 6-11-1 Omorinishi, Ota-ku, Tokyo, 143-8541, Japan

    Satoshi Tabako, Masahiko Harada & Kunio Sugiyama

  2. Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Medical Center Omori Hospital, 6-11-1 Omorinishi, Ota-ku, Tokyo, 143-8541, Japan

    Hiroshi Ohara & Takanori Ikeda

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  1. Satoshi Tabako
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  2. Masahiko Harada
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  3. Kunio Sugiyama
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Correspondence to Satoshi Tabako.

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Conflict of interest

None of the authors has any conflict of interest in the research associated with this article.

Ethical standards

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. This research was approved by the Ethics Committee of Toho University Medical Center Omori Hospital (approval No. M17264) and was conducted after the Committee made a decision that informed consent was not required.

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Tabako, S., Harada, M., Sugiyama, K. et al. Association of left ventricular myocardial dysfunction with diabetic polyneuropathy. J Med Ultrasonics 46, 69–79 (2019). https://doi.org/10.1007/s10396-018-0898-6

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