Myopia progression over a 4-year period after laser-assisted refractive surgery in patients in their 20s and 30s



To investigate the increase in refractive error (RE) and axial length (AL) in myopia patients in their 20s and 30s after laser-assisted in situ keratomileusis (LASIK) or epipolis-LASIK (epi-LASIK).

Study design

Retrospective cohort study.


This retrospective study involved 280 eyes of 140 myopia patients who underwent LASIK or epi-LASIK at the Baptist Eye Institute, Kyoto, Japan and who were followed for more than 5 years postoperatively. The patients were divided into 2 groups according to age: group A (age range, 20–29 years) and group B (age range, 30–39 years). In all patients, the RE and AL were measured at 1, 2, 3, 4, and 5 years postoperatively, and the 2 groups were compared in terms of each surgical method.


The patients’ mean age at surgery was 30.6 ± 4.9 years. No significant difference was found between the 2 groups in terms of the preoperative mean spherical equivalent (SE) or AL. In the LASIK group, the mean changes in SE during the 4 years of study in groups A and B were + 0.054 ± 0.256 D and + 0.052 ± 0.327 D, respectively (P = .93, NS), and the postoperative increases in AL were 0.059 ± 0.134 mm and 0.027 ± 0.133 mm, respectively (P = .08, NS). In the epi-LASIK group, the mean change in SE during the 4 years of study in groups A and B were  −0.438 ± 0.207 D and −0.259 ± 0.454 D, respectively (P = .41, NS), and the postoperative increases in AL were 0.124 ± 0.141 mm and 0.094 ± 0.166 mm, respectively (P = .46, NS).


Our findings showed no significant difference in myopia progression in patients in their 20s and 30s during a 4-year period after either LASIK or epi-LASIK.

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The authors wish to thank John Bush for reviewing the manuscript.

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Correspondence to Miho Sasaki.

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M. Sasaki, None; O. Hieda, None; K. Wakimasu, None; K. Yamamura, None; S. Kinoshita, None; C. Sotozono, None.

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Corresponding Author: Miho Sasaki

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Sasaki, M., Hieda, O., Wakimasu, K. et al. Myopia progression over a 4-year period after laser-assisted refractive surgery in patients in their 20s and 30s. Jpn J Ophthalmol 64, 450–454 (2020).

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  • Age
  • Disease progression
  • Epi-LASIK
  • Myopia