Skip to main content

Advertisement

SpringerLink
Log in

Current status of late and recurrent intraocular lens dislocation: analysis of real-world data in Japan

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To describe relevant patient demographic characteristics and investigate the influence of known risk factors for late intraocular lens (IOL) dislocation. To explore the associations between these risk factors and the incidence of recurrent IOL dislocation.

Study design

Retrospective cohort study.

Methods

This study was performed using Nationwide Diagnostic Procedure Combination data in Japan from April 1, 2008 through July 31, 2016. Descriptive statistics for late and recurrent IOL dislocation, incidence rates, and risk factors for recurrent IOL dislocation were analyzed using a Cox proportional hazard model.

Results

We identified 678 patients with late IOL dislocation. Most were men (72%, 488/678), and the men were younger than their women counterparts (mean age 65.2 years vs. 74.5 years). The incidence rate of recurrent IOL dislocation was 5.1 per 100 person-years. All 20 cases of recurrent IOL dislocation were observed within the year following surgery. There were no significant associations between potential risk factors and recurrent IOL dislocation (adjusted hazard ratio [HR] 1.53, 95% confidence interval [CI] 0.55–4.26 for diabetes mellitus; adjusted HR 0.77, 95%CI 0.09–6.40 for atopic dermatitis); no recurrences occurred in patients with pseudoexfoliation syndrome, retinitis pigmentosa, or connective tissue disease.

Conclusions

Late IOL dislocation occurs more frequently in men. We found that recurrent IOL dislocation was rare during long-term follow-up and there were no significant associations between the potential risk factors and recurrent IOL dislocation. Further studies are needed to clarify the sex-related differences involved in IOL dislocation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. The international agency for the prevention of blindness. https://www.iapb.org/iapb-regions/western-pacific/japan/. Accessed March 13, 2018

  2. Gimbel HV, Condon GP, Kohnen T, Olson RJ, Halkiadakis I. Late in-the-bag intraocular lens dislocation: incidence, prevention, and management. J Cataract Refract Surg. 2005;31:2193–204.

    Article  PubMed  Google Scholar 

  3. Ascaso FJ, Huerva V, Grzybowski A. Epidemiology, Etiology, and Prevention of Late IOL-Capsular Bag Complex Dislocation: Review of the Literature. J Ophthal. 2015;2015:805706.

    Google Scholar 

  4. Pueringer SL, Hodge DO, Erie JC. Risk of late intraocular lens dislocation after cataract surgery, 1980–2009: a population-based study. Am J Ophthalmol. 2011;152:618–23.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Monestam EI. Incidence of dislocation of intraocular lenses and pseudophakodonesis 10 years after cataract surgery. Ophthalmology. 2009;116:2315–20.

    Article  PubMed  Google Scholar 

  6. Dabrowska-Kloda K, Kloda T, Boudiaf S, Jakobsson G, Stenevi U. Incidence and risk factors of late in-the-bag intraocular lens dislocation: Evaluation of 140 eyes between 1992 and 2012. J Cataract Refract Surg. 2015;41:1376–82.

    Article  PubMed  Google Scholar 

  7. Gross JG, Kokame GT, Weinberg DV. In-the-bag intraocular lens dislocation. Am J Ophthalmol. 2004;137:630–5.

    PubMed  Google Scholar 

  8. Vazquez-Ferreiro P, Carrera-Hueso FJ, Fikri-Benbrahim N, Barreiro-Rodriguez L, Diaz-Rey M, Ramon Barrios MA. Intraocular lens dislocation in pseudoexfoliation: a systematic review and meta-analysis. Acta Ophthalmol. 2017;95:e164–9.

    Article  PubMed  Google Scholar 

  9. Yamazaki S, Nakamura K, Kurosaka D. Intraocular lens subluxation in a patient with facial atopic dermatitis. J Cataract Refract Surg. 2001;27:337–8.

    Article  CAS  PubMed  Google Scholar 

  10. Bassily R, Lencova A, Rajan MS. Bilateral rupture of the posterior capsule and intraocular lens dislocation from excessive eye rubbing. J Cataract Refract Surg. 2016;42:329–31.

    Article  PubMed  Google Scholar 

  11. Assia EI, Apple DJ, Morgan RC, Legler UF, Brown SJ. The relationship between the stretching capability of the anterior capsule and zonules. Invest Ophthalmol Vis Sci. 1991;32:2835–9.

    CAS  PubMed  Google Scholar 

  12. Fernández-Buenaga R, Alio JL, Pérez-Ardoy AL, Larrosa-Quesada A, Pinilla-Cortés L, Barraquer R, et al. Late in-the-bag intraocular lens dislocation requiring explantation: Risk factors and outcomes. Eye (Basingstoke). 2013;27:795–802.

    Google Scholar 

  13. Steeples LR, Jones NP. Late in-the-bag intraocular lens dislocation in patients with uveitis. Br J Ophthalmol. 2015;99:1206–10.

    Article  PubMed  Google Scholar 

  14. Davis D, Brubaker J, Espandar L, Stringham J, Crandall A, Werner L, et al. Late in-the-bag spontaneous intraocular lens dislocation: evaluation of 86 consecutive cases. Ophthalmology. 2009;116:664–70.

    Article  PubMed  Google Scholar 

  15. Su WW, Chang SH. Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. J Cataract Refract Surg. 2004;30:1805–7.

    Article  PubMed  Google Scholar 

  16. Tanaka S, Seto K, Kawakami K. Pharmacoepidemiology in Japan: medical databases and research achievements. J Pharm Health Care Sci. 2015;1:16.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Ishii M. DRG/PPS and DPC/PDPS as prospective payment systems. JMAJ. 2012;55:279–91.

    PubMed  Google Scholar 

  18. Japanese Ministry of Health, Labour and Welfare. The DPC amd preparing hospitals scale. 2016 (in Japanese) http://www.mhlw.go.jp/file/05-Shingikai-12404000-Hokenkyoku-Iryouka/0000121094.pdf. Accessed July 30, 2017.

  19. Yamamoto T, Iwase A, Araie M, Suzuki Y, Abe H, Shirato S, et al. The Tajimi Study report 2: prevalence of primary angle closure and secondary glaucoma in a Japanese population. Ophthalmology. 2005;112:1661–9.

    Article  PubMed  Google Scholar 

  20. Miyazaki M, Kubota T, Kubo M, Kiyohara Y, Iida M, Nose Y, et al. The prevalence of pseudoexfoliation syndrome in a Japanese population: the Hisayama study. J Glaucoma. 2005;14:482–4.

    Article  PubMed  Google Scholar 

  21. Yardley AM, Ali A, Najm-Tehrani N, Mireskandari K. Refractive and visual outcomes after surgery for pediatric traumatic cataract. J Cataract Refract Surg. 2018;44:85–90.

    Article  PubMed  Google Scholar 

  22. Kim SS, Smiddy WE, Feuer W, Shi W. Management of dislocated intraocular lenses. Ophthalmology. 2008;115:1699–704.

    Article  PubMed  Google Scholar 

  23. Yotsukura-Tsutsui E, Koto T, Tsubota K, Ozawa Y. Predisposing factors for intraocular lens dislocation treated by pars plana vitrectomy: Involvement of atopic dermatitis. J Cataract Refract Surg. 2015;41:892–4.

    Article  PubMed  Google Scholar 

  24. Takeuchi S, Esaki H, Furue M. Epidemiology of atopic dermatitis in Japan. J Dermatol. 2014;41:200–4.

    Article  PubMed  Google Scholar 

  25. Azuma N, Hida T, Katsura H, Takeuchi S, Danjo S, Tano Y. Retrospective survey of surgical outcomes on rhegmatogenous retinal detachments associated with atopic dermatitis. Arch Ophthalmol. 1996;114:281–5.

    Article  CAS  PubMed  Google Scholar 

  26. Hayashi H, Hayashi K, Nakao F, Hayashi F. Area reduction in the anterior capsule opening in eyes of diabetes mellitus patients. J Cataract Refract Surg. 1998;24:1105–10.

    Article  CAS  PubMed  Google Scholar 

  27. Koike T, Baba T, Nizawa T, Oshitari T, Yamamoto S. Characteristics of patients with spontaneous dislocation of in-the-bag intraocular lens after pars plana vitrectomy. Jpn J Ophthalmol. 2017;61:267–70.

    Article  PubMed  Google Scholar 

  28. Vote BJ, Tranos P, Bunce C, Charteris DG, Da Cruz L. Long-term outcome of combined pars plana vitrectomy and scleral fixated sutured posterior chamber intraocular lens implantation. Am J Ophthalmol. 2006;141:308–12.

    Article  PubMed  Google Scholar 

  29. Bading G, Hillenkamp J, Sachs HG, Gabel VP, Framme C. Long-term safety and functional outcome of combined pars plana vitrectomy and scleral-fixated sutured posterior chamber lens implantation. Am J Ophthalmol. 2007;144:371–7.

    Article  PubMed  Google Scholar 

  30. Hayashi K, Hirata A, Hayashi H. Possible predisposing factors for in-the-bag and out-of-the-bag intraocular lens dislocation and outcomes of intraocular lens exchange surgery. Ophthalmology. 2007;114:969–75.

    Article  PubMed  Google Scholar 

  31. Hayashi K, Ogawa S, Manabe S, Hirata A, Yoshimura K. A classification system of intraocular lens dislocation sites under operating microscopy, and the surgical techniques and outcomes of exchange surgery. Graefes Arch Clin Exp Ophthalmol. 2016;254:505–13.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Yamana H, Moriwaki M, Horiguchi H, Kodan M, Fushimi K, Yasunaga H. Validity of diagnoses, procedures, and laboratory data in Japanese administrative data. J Epidemiol. 2017;27:476–82.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.

    Article  CAS  Google Scholar 

  34. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45:613–9.

    Article  CAS  Google Scholar 

  35. Wagoner MD, Cox TA, Ariyasu RG, Jacobs DS, Karp CL. Intraocular lens implantation in the absence of capsular support. Ophthalmology. 2003;110:840–59.

    Article  PubMed  Google Scholar 

  36. Gabor SG, Pavlidis MM. Sutureless intrascleral posterior chamber intraocular lens fixation. J Cataract Refract Surg. 2007;33:1851–4. https://doi.org/10.1016/j.jcrs.2007.07.013.

    Article  PubMed  Google Scholar 

  37. Maggi R, Maggi C. Sutureless scleral fixation of intraocular lenses. J Cataract Refract Surg. 1997;23:1289–94.

    Article  CAS  PubMed  Google Scholar 

  38. Ohta T, Toshida H, Murakami A. Simplified and safe method of sutureless intrascleral posterior chamber intraocular lens fixation: Y-fixation technique. J Cataract Refract Surg. 2014;40:2–7.

    Article  PubMed  Google Scholar 

  39. Jakobsson G, Zetterberg M, Lundstrom M, Stenevi U, Grenmark R, Sundelin K. Late dislocation of in-the-bag and out-of-the bag intraocular lenses: ocular and surgical characteristics and time to lens repositioning. J Cataract Refract Surg. 2010;36:1637–44.

    Article  PubMed  Google Scholar 

  40. Krepste L, Kuzmiene L, Miliauskas A, Januleviciene I. Possible predisposing factors for late intraocular lens dislocation after routine cataract surgery. Medicina (Kaunas, Lithuania). 2013;49:229–34.

    PubMed  Google Scholar 

Download references

Acknowledgements

The authors thank Dr. Toshifumi Yamashita for making useful comments on the study design.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Sumihiro Kawano, Takehiro Yamashita & Taiji Sakamoto

  2. Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan

    Sumihiro Kawano, Masato Takeuchi & Koji Kawakami

  3. Department of Clinical Biostatistics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Shiro Tanaka

Authors
  1. Sumihiro Kawano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masato Takeuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shiro Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takehiro Yamashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Taiji Sakamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Koji Kawakami
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Koji Kawakami.

Ethics declarations

Conflicts of interest

S. Kawano, None; M. Takeuchi, None; S. Tanaka, None; T. Yamashita, None; T. Sakamoto, None; K. Kawakami, Consultant fees (Kaken, Kyowa Hakko Kirin, Olympus, Otsuka), Honorarium (Behringer Ingelheim Japan, Daiichi Sankyo, Eisai, Mitsubishi Tanabe Pharma, Novartis, Sanofi, Shionogi, Takeda), Lecture fee (Santen).

Additional information

Corresponding author: Koji Kawakami

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kawano, S., Takeuchi, M., Tanaka, S. et al. Current status of late and recurrent intraocular lens dislocation: analysis of real-world data in Japan. Jpn J Ophthalmol 63, 65–72 (2019). https://doi.org/10.1007/s10384-018-0637-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-018-0637-y

Keywords

Search

Navigation