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Topical non-steroidal anti-inflammatory drugs for the treatment of cystoid macular edema post Descemet’s stripping automated endothelial keratoplasty

  • Clinical Investigation
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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the effectiveness of topical non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of cystoid macular edema (CME) post Descemet’s stripping automated endothelial keratoplasty (DSAEK).

Study design

Retrospective observational study

Methods

In this study of 334 patients who underwent DSAEK at the Baptist Eye Institute, Kyoto, Japan between July 2011 and December 2015, 18 patients with postoperative CME (determined by optical coherence tomography) treated with topical NSAIDs after the onset of CME were included.

Results

At CME onset, 17 of the 18 patients were treated with bromfenac eye drops and 1 was treated with nepafenac eye drops. Post initiation of treatment with topical NSAIDs, CME in 17 (94.4%) of the 18 patients improved at 1 month and all cases completely recovered within 3 months. At 12-months post initiation of treatment, 61.1% (n = 11) of patients achieved a visual acuity (VA) of 20/40 or better, and there was no significant difference of VA between the patients with or without an episode of postoperative CME (P = 0.55).

Conclusion

The administration of topical NSAID eye drops was found to be effective in treating patients with CME post DSAEK.

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Acknowledgements

The authors wish to thank John Bush for reviewing the manuscript and greatly thank Dr. Nobuhiro Terao for scientific suggestions regarding retinal imaging analysis. There is no competing interest for any of the authors. This study was supported in part by research funds from the Kyoto Foundation for the Promotion of Medical Science and JSPS KAKENHI Grant Number JP16K20324. design of the study (S.K.), collection of data (K.Kita.), management of data (K.Kita.), analysis of data (K.Kita.), interpretation of data (K.Kita.), writing of the article (K.Kita., S.K.), approval of the manuscript (K.Kita., K.Kayu, K.W., T.I., O.H., K.M., C.S., S.K.), statistical expertise (K.K), obtaining of funding (K.K and S.K.), searching the literature (K.K.).

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Authors and Affiliations

  1. Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan

    Koji Kitazawa & Shigeru Kinoshita

  2. Baptist Eye Institute, Kyoto, Japan

    Koji Kitazawa, Kanae Kayukawa, Koichi Wakimasu & Shigeru Kinoshita

  3. Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Tsutomu Inatomi, Osamu Hieda, Kazuhiko Mori & Chie Sotozono

Authors
  1. Koji Kitazawa
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  2. Kanae Kayukawa
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  3. Koichi Wakimasu
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  4. Tsutomu Inatomi
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  5. Osamu Hieda
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  6. Kazuhiko Mori
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  7. Chie Sotozono
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  8. Shigeru Kinoshita
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Corresponding author

Correspondence to Shigeru Kinoshita.

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Conflicts of interest

K. Kitazawa, None; K. Kayukawa, None; K. Wakimasu, None; T. Inatomi, None; O. Hieda, None; K. Mori, None; C. Sotozono, None; S. Kinoshita, None.

Additional information

Corresponding author: Shigeru Kinoshita

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Kitazawa, K., Kayukawa, K., Wakimasu, K. et al. Topical non-steroidal anti-inflammatory drugs for the treatment of cystoid macular edema post Descemet’s stripping automated endothelial keratoplasty. Jpn J Ophthalmol 62, 615–620 (2018). https://doi.org/10.1007/s10384-018-0621-6

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  • DOI: https://doi.org/10.1007/s10384-018-0621-6

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