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Japanese Journal of Ophthalmology

, Volume 62, Issue 3, pp 274–279 | Cite as

Extended field imaging using swept-source optical coherence tomography angiography in retinal vein occlusion

  • Shinji Kakihara
  • Takao Hirano
  • Yasuhiro Iesato
  • Akira Imai
  • Yuichi Toriyama
  • Toshinori Murata
Clinical Investigation
  • 174 Downloads

Abstract

Purpose

To evaluate the degree of ischemia in eyes with retinal vein occlusion (RVO) using swept-source optical coherence tomography angiography (SS-OCTA) with the extended field imaging (EFI) technique, which extends the area encompassed by SS-OCTA by scanning through trial frames fitted with a +20-diopter lens.

Study Design

Retrospective observational study.

Methods

Twenty-three consecutive eyes of 22 patients with RVO underwent 12 × 12 mm SS-OCTA imaging both with and without EFI for determination of extension rate. Two graders blinded to the clinical data evaluated the degree of retinal ischemia in paired EFI-SS-OCTA and fluorescein angiography (FA) images, and the concordance rates between the grades were statistically examined.

Results

One EFI-SS-OCTA image was not successfully obtained due to motion artifacts caused by the patient’s poor central vision, while SS-OCTA images without EFI were captured in all 23 eyes. The average extension rate of EFI-SS-OCTA over SS-OCTA was 1.39 ± 0.06 and the average scanning area was enlarged by 76.4%. Two graders evaluated the degree of retinal ischemia by measuring nonperfusion areas as the sum of disc areas/diameters. Although their assessments of the EFI-SS-OCTA images were in complete agreement (Cohen’s Unweighted Kappa coefficient = 1.00), concordance using FA images was only moderate (Cohen’s Unweighted Kappa coefficient = 0.60).

Conclusion

EFI-SS-OCTA noninvasively produces wider field images of retinal vasculature with one capture and provides resolution sufficient to accurately evaluate retinal capillary nonperfusion in RVO.

Keywords

Retinal vein occlusion Optical coherence tomography Optical coherence tomography angiography Capillary nonperfusion Fluorescein angiography 

Notes

Acknowledgements

The authors thank Yoshitaka Takano, a certified orthoptist at Shinshu University hospital, for collecting data and other paramedical staff in our team for helping to make this study possible.

Funding

Supported by JSPS KAKENHI Grant Number JP 16K11283.

Conflicts of interest

S. Kakihara, None; T. Hirano, Lecture fees (Bayer, Novartis, Santen, Zeiss); Y. Iesato, Lecture fees (Bayer, Novartis, Santen); A. Imai, None; Y. Toriyama, Lecture fees (Bayer, Nidek, Novartis); T. Murata, Lecture fees (Bayer, Novartis, Santen, Zeiss).

Supplementary material

10384_2018_590_MOESM1_ESM.pdf (20 kb)
Supplementary material 1 (PDF 20 kb)
10384_2018_590_MOESM2_ESM.pdf (26 kb)
Supplementary material 2 (PDF 25 kb)

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Copyright information

© Japanese Ophthalmological Society 2018

Authors and Affiliations

  • Shinji Kakihara
    • 1
  • Takao Hirano
    • 1
  • Yasuhiro Iesato
    • 1
  • Akira Imai
    • 1
  • Yuichi Toriyama
    • 1
  • Toshinori Murata
    • 1
  1. 1.Department of OphthalmologyShinshu University School of MedicineMatsumotoJapan

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