Skip to main content

Advertisement

SpringerLink
Log in

Periocular inverted follicular keratosis: a retrospective series over 17 years

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the demographic, clinical, and histopathologic characteristics of periocular inverted follicular keratosis (IFK), a very rare lesion with poorly defined characteristics.

Study design

Retrospective case series.

Methods

We evaluated 11 patients with clinically diagnosed IFK confirmed by histologic analysis. Data were collected on the patients’ demographics, clinical presentation and course of the disease, signs and symptoms, location of the lesion, and outcomes of treatment.

Results

The patients’ mean age was 71 years (range, 32–91 years). Seven (64%) of the patients were female. Eight of the patients (72.7%) had no symptoms, two (18.2%) reported itching, and one (9.1%) had edema and bleeding of the lesion. The lesion affected the upper eyelid in 4 of the patients (36%), the lower lid in 3 of the patients (27%), and the inner canthus in 4 of the patients (36%).

Conclusions

IFK has no specific clinical characteristic and thus requires histologic confirmation for its diagnosis and appropriate management.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Yanoff M. Most inverted follicular keratoses are probably verrucal vulgares. Am J Dermatopathol. 1983;5:475.

    Article  PubMed  CAS  Google Scholar 

  2. Neff AG, Chahal HS, Carter KD. Benign eyelid lesions. In: Yanoff M, Duker JS, editors. Ophthalmology. 5th ed. Amsterdam: Elsevier Health Sciences; 2018. p. 1263–303.

    Google Scholar 

  3. Mohamed M. Inverted follicular keratosis of the lip. Pan Afr Med J. 2014;18:304.

    PubMed  PubMed Central  Google Scholar 

  4. Soylu L, Akcali C, Aydogan LB, Ozsahinoglu C, Tuncer I. Inverted follicular keratosis. Am J Otolaryngol. 1993;14:247–8.

    Article  PubMed  CAS  Google Scholar 

  5. Kwitko ML, Boniuk M, Zimmerman LE. Eyelid tumors with reference to lesions confused with squamous cell carcinoma. I. Incidence and errors in diagnosis. Arch Ophthalmol. 1963;69:693–7.

    Article  PubMed  CAS  Google Scholar 

  6. Schweitzer JG, Yanoff M. Inverted follicular keratosis: a report of two recurrent cases. Ophthalmology. 1987;94:1465–8.

    Article  PubMed  CAS  Google Scholar 

  7. Doxanas MT, Iliff WJ, Iliff NT, Green WR. Squamous cell carcinoma of the eyelids. Ophthalmology. 1987;94:538–41.

    Article  PubMed  CAS  Google Scholar 

  8. Mencia Gutierrez E, Gutierrez Diaz E, Ricoy JR, Gomez Ledesma I, Monescillo J, Garcia Torre JP. Benign hair-follicle derived eyelids tumors in adults [in Spanish]. Arch Soc Esp Oftalmol. 2002;77:605–10.

    Article  PubMed  CAS  Google Scholar 

  9. Ruhoy SM, Thomas D, Nuovo GJ. Multiple inverted follicular keratoses as a presenting sign of Cowden’s syndrome: case report with human papillomavirus studies. J Am Acad Dermatol. 2004;51:411–5.

    Article  PubMed  Google Scholar 

  10. Pointdujour-Lim R, Marous MR, Satija CE, Douglass AM, Eagle RC Jr, Shields JA, et al. Cutaneous horn of the eyelid in 13 cases. Ophthal Plast Reconstr Surg. 2017;33:233–6.

    Article  PubMed  Google Scholar 

  11. Mehregan AH. Inverted follicular keratosis. Arch Dermatol. 1964;89:229–35.

    Article  PubMed  CAS  Google Scholar 

  12. Mehregan AH. Inverted follicular keratosis is a distinct follicular tumor. Am J Dermatopathol. 1983;5:467–70.

    Article  PubMed  CAS  Google Scholar 

  13. Reed RJ, Pulitzer DR. Inverted follicular keratosis and human papillomaviruses. Am J Dermatopathol. 1983;5:453–65.

    Article  PubMed  CAS  Google Scholar 

  14. Shih CC, Yu HS, Tung YC, Tsai KB, Cheng ST. Inverted follicular keratosis. Kaohsiung J Med Sci. 2001;17:50–4.

    PubMed  CAS  Google Scholar 

  15. Lever WF. Inverted follicular keratosis is an irritated seborrheic keratosis. Am J Dermatopathol. 1983;5:474.

    Article  PubMed  CAS  Google Scholar 

  16. Boniuk M, Zimmerman LE. Eyelid tumors with reference to lesions confused with squamous cell carcinoma. II. Inverted follicular keratosis. Arch Ophthalmol. 1963;69:698–707.

    Article  PubMed  CAS  Google Scholar 

  17. Sassani JW, Yanoff M. Inverted follicular keratosis. Am J Ophthalmol. 1979;87:810–3.

    Article  PubMed  CAS  Google Scholar 

  18. Sim-Davis D, Marks R, Wilson-Jones E. The inverted follicular keratosis: a surprising variant of seborrheic wart. Acta Derm Venereol. 1976;56:337–44.

    PubMed  CAS  Google Scholar 

  19. Battistella M, Peltre B, Cribier B. Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. J Cutan Pathol. 2010;37:1057–63.

    Article  PubMed  Google Scholar 

  20. Scheie HG, Yanoff M, Sassani JW. Inverted follicular keratosis clinically mimicking malignant melanoma. Ann Ophthalmol. 1977;9:949–52.

    PubMed  CAS  Google Scholar 

  21. Abbas OL, Borman H. Basal cell carcinoma: a single-center experience. ISRN Dermatol. 2012;2012:246542.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Armengot-Carbo M, Abrego A, Gonzalez T, Alarcon I, Alos L, Carrera C, et al. Inverted follicular keratosis: dermoscopic and reflectance confocal microscopic features. Dermatology. 2013;227:62–6.

    Article  PubMed  CAS  Google Scholar 

  23. Llambrich A, Zaballos P, Taberner R, Terrasa F, Banuls J, Pizarro A, et al. Dermoscopy of inverted follicular keratosis: study of 12 cases. Clin Exp Dermatol. 2016;41:468–73.

    Article  PubMed  CAS  Google Scholar 

  24. Thom GA, Quirk CJ, Heenan PJ. Inverted follicular keratosis simulating malignant melanoma. Australas J Dermatol. 2004;45:55–7.

    Article  PubMed  Google Scholar 

  25. Villaret AB, Gily B, Aga A. Inverted follicular keratosis of the nasal vestibule. Otolaryngol Head Neck Surg. 2009;141:288–9.

    Article  PubMed  Google Scholar 

  26. Pe’er J. Pathology of eyelid tumors. Indian J Ophthalmol. 2016;64:177–90.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Patterson JW. Tumors of cutaneous appendages. In: Weedson’s skin pathology. 4th ed. Edinburgh: Elsevier Health Sciences; 2015. p. 903–65.

  28. Karadag AS, Ozlu E, Uzuncakmak TK, Akdeniz N, Cobanoglu B, Oman B. Inverted follicular keratosis successfully treated with imiquimod. Indian Dermatol Online J. 2016;7:177–9.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Spielvogel RL, Austin C, Ackerman AB. Inverted follicular keratosis is not a specific keratosis but a verruca vulgaris (or seborrheic keratosis) with squamous eddies. Am J Dermatopathol. 1983;5(5):427–42.

    Article  Google Scholar 

Download references

Conflicts of interest

C. D.-Montero, None; D. G. González, None; E. P. Martinez, None; S. Schellini, None; A. G.-Ferreiro, None.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Rio Hortega University Hospital, Dulzaina St. 2, 47012, Valladolid, Spain

    Cecilia Díez-Montero & Alicia Galindo-Ferreiro

  2. Department of Pathology, Rio Hortega University Hospital, Valladolid, Spain

    Diego González González & Elena Pérez Martínez

  3. Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia

    Silvana Schellini

Authors
  1. Cecilia Díez-Montero
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Diego González González
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Elena Pérez Martínez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Silvana Schellini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alicia Galindo-Ferreiro
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alicia Galindo-Ferreiro.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Corresponding author: Cecilia Díez-Montero

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Díez-Montero, C., González González, D., Pérez Martínez, E. et al. Periocular inverted follicular keratosis: a retrospective series over 17 years. Jpn J Ophthalmol 63, 210–214 (2019). https://doi.org/10.1007/s10384-018-00650-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-018-00650-7

Keywords

Search

Navigation