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Malondialdehyde kinetics following coronary artery bypass grafting and its relation to osteopontin

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Summary

Background

Cardiac surgery is associated with inflammation and oxidative stress; malondialdehyde (MDA) is a marker of oxidative stress and osteopontin (OPN) is a proinflammatory cytokine. We studied MDA kinetics following coronary artery bypass grafting (CABG) and its relation to OPN.

Methods

We evaluated 50 consecutive patients (60 ± 10 year-old, 44 men and 6 women) with stable coronary artery disease and left ventricular ejection fraction of 50 ± 8 % undergoing elective CABG on pump. Peripheral plasma samples were drawn at baseline, 24 and 72 h postoperatively. OPN was evaluated at baseline and MDA and cardiac enzymes at all time points.

Results

MDA levels increased significantly at 72 h postoperative compared with preoperative and 24 h postoperative levels whereas there was no difference between the pre and first postoperative values (p = 0.67). MDA change was positively correlated with the change in troponin at baseline and at 72 h (r = 0.6, p = 0.022) as well as with preoperative OPN levels (r = 0.28, p = 0.047). There was a significant positive correlation between MDA at 72 h and age (r = 0.27, p = 0.039). In addition, MDA change differed significantly in relation to diabetes at baseline and at 72 h—2.99 (4.77) in diabetics versus 0.69 (3.82) in non-diabetics (p = 0.05).

Conclusions

MDA increases post on-pump CABG but only at 72 h and this increase correlates with preoperative OPN levels. In addition, MDA increase is related to age and diabetes as well as troponin increase following surgery.

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Conflict of interest

Eftihia Sbarouni, Panagiota Georgiadou, Constantinos Mihas, Antigoni Chaidaroglou, Demitris Degiannis, and Vassilis Voudris declare that they have no conflict of interest.

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Authors and Affiliations

  1. 2nd Division of Interventional Cardiology, Onassis Cardiac Surgery Center, 356 Syngrou Avenue, 176 74, Athens, Greece

    E. Sbarouni MD, FESC, FACC, P. Georgiadou MD, C. Mihas MD, MSc, PhD, FESC & V. Voudris MD, FESC,FACC

  2. Molecular Immunopathology and Histocompatibility Laboratory, Onassis Cardiac Surgery Center, Athens, Greece

    A. Chaidaroglou PhD & D. Degiannis MD

Authors
  1. E. Sbarouni MD, FESC, FACC
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  2. P. Georgiadou MD
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  3. C. Mihas MD, MSc, PhD, FESC
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  4. A. Chaidaroglou PhD
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  5. D. Degiannis MD
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  6. V. Voudris MD, FESC,FACC
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Correspondence to P. Georgiadou MD.

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Sbarouni, E., Georgiadou, P., Mihas, C. et al. Malondialdehyde kinetics following coronary artery bypass grafting and its relation to osteopontin. Eur Surg 46, 165–168 (2014). https://doi.org/10.1007/s10353-014-0280-x

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  • DOI: https://doi.org/10.1007/s10353-014-0280-x

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