Skip to main content
SpringerLink
Log in

Parathyroid carcinoma in primary hyperparathyroidism: single institution experience

  • Original Article
  • Published:
European Surgery Aims and scope Submit manuscript

Summary

Background

Parathyroid carcinoma as a cause of primary hyperparathyroidism is very rare. Clear consensus regarding the optimal management of patients with this condition is not available. We aimed to report our experience with this entity.

Methods

We analyzed medical records of patients who were operated for primary hyperparathyroidism and parathyroid carcinoma in the Centre for Endocrine Surgery in Belgrade, between January 2000 and December 2007.

Results

Seven patients (four men and three women) were operated for parathyroid carcinoma and primary HPT in our institution in this period. The age at initial diagnosis (mean ± SD) was 53.5 ± 7.6 years. All patients had hypercalcemia (mean 3.53 mmol/l) and very elevated parathyroid hormone (mean 1,530 pg/ml). Extirpation of the parathyroid tumor was performed in two patients, while in five patients parathyroidectomy was performed en block with all involved tissue. Average follow up was 47 months. One patient died for another disease, one was found to have increased calcium and parathyroid hormone levels postoperatively, while the remaining five were free of disease.

Conclusions

Surgery remains central in the management of patients with parathyroid carcinoma. Still, further multicentric studies should be performed for consistent treatment guidelines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Wynne AG, van Heerden J, Carney JA, Fitzpatrick LA. Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine (Baltimore). 1992;71:197–205.

    CAS  Google Scholar 

  2. Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, et al. Parathyroid carcinoma: a 22-year experience. Head Neck. 2004;26:716–26.

    Article  PubMed  Google Scholar 

  3. Robert J, Trombetti A, Garcia A, Pache JC, Herrmann F, Spiliopoulos A, et al. Primary hyperparathyroidism: can parathyroid carcinoma be anticipated on clinical and biochemical grounds? Report of nine cases and review of the literature. Ann Surg Oncol. 2005;12:526–32.

    Article  PubMed  Google Scholar 

  4. Mittendorf EA, McHenry CR. Parathyroid carcinoma. J Surg Oncol. 2005;89:136–42.

    Article  PubMed  CAS  Google Scholar 

  5. Shane E. Clinical review 122: parathyroid carcinoma. J Clin Endocrinol Metab. 2001;86:485–93.

    Article  PubMed  CAS  Google Scholar 

  6. Ou HY, Hung WH, Hsu WH, Yu EH, Wu TJ. Variability of clinical presentations in three cases of parathyroid carcinoma. J Formos Med Assoc. 2003;102:266–69.

    PubMed  Google Scholar 

  7. Hundahl S, Fleming I, Fremgen A, Menck HR. Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995. Cancer. 1999;86:538–44.

    Article  PubMed  CAS  Google Scholar 

  8. Zivaljevic V, Krgovic K, Tatic S, Havelka M, Dimitrijevic Z, Diklic A, et al. Parathyroid cancer in a hemodialysis patient: a case report. Tumori. 2002;88:430–3.

    PubMed  Google Scholar 

  9. Cavaco BM, Barros L, Pannett AA, Ruas L, Carvalheiro M, Ruas MM, et al. The hyperparathyroidism-jaw tumor syndrome in a Portuguese kindred. QJM. 2001;94:213–22.

    Article  PubMed  CAS  Google Scholar 

  10. Wassif WS, Moniz CF, Friedman E, Wong S, Weber G, Nordenskjold M, et al. Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer. J Clin Endocrinol Metab. 1993;77:1485–9.

    Article  PubMed  CAS  Google Scholar 

  11. Imanishi Y, Palanisamy N, Tahara H, Vickery A, Cryns VL, Gaz RD, et al. Molecular pathogenetic analysis of parathyroid carcinoma. J Bone Miner Res. 1999;14:405.

    Google Scholar 

  12. Kebebew E, Arici C, Duh QY, Clark OH. Localization and reoperation results for persistent and recurrent parathyroid carcinoma. Arch Surg. 2001;136:878–85.

    Article  PubMed  CAS  Google Scholar 

  13. Schantz A, Castleman B. Parathyroid carcinoma: a study of 70 cases. Cancer. 1973;31:600–5.

    Article  PubMed  CAS  Google Scholar 

  14. Lee PK, Jarosek SL, Virnig BA, Evasovich M, Tuttle TM. Trends in the incidence and treatment of parathyroid cancer in the United States. Cancer. 2007;109(9):1736–41.

    Google Scholar 

  15. Silverberg SJ, Rubin MR, Faiman C, Peacock M, Shoback DM, Smallridge RC, et al. Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma. J Clin Endocrinol Metab. 2007;92:3803–8.

    Article  PubMed  CAS  Google Scholar 

  16. Miki H, Sumitomo M, Inoue H, Kita S, Monden Y. Parathyroid carcinoma in patients with chronic renal failure on maintenance hemodialysis. Surgery. 1996;120:897–901.

    Article  PubMed  CAS  Google Scholar 

  17. Obara T, Fujimoto Y. Diagnosis and treatment of patients with parathyroid carcinoma: an update and review. World J Surg. 1991;15:738–44.

    Article  PubMed  CAS  Google Scholar 

  18. Shane E, Bilezikian J. Parathyroid carcinoma: a review of 62 patients. Endocr Rev. 1982;3:218–26.

    Article  PubMed  CAS  Google Scholar 

  19. Sandelin K, Auer G, Bondeson L, Grimelius L, Farnebo LO. Prognostic factors in parathyroid cancer: a review of 95 cases. World J Surg. 1992;16:724–31.

    Google Scholar 

  20. Khan MW, Worcester EM, Straus FH 2nd, Khan S, Staszak V, Kaplan EL. Parathyroid carcinoma in secondary and tertiary hyperparathyroidism. J Am Coll Surg. 2004;199:312–9.

    Article  PubMed  Google Scholar 

  21. Holmes EC, Morton DL, Ketcham AS. Parathyroid carcinoma: a collective review. Ann Surg. 1969;169:631–40.

    Article  PubMed  CAS  Google Scholar 

  22. Ippolito G, Palazzo FF, Sebag F, De Micco C, Henry JF. Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma. Br J Surg. 2007;94(5):566–70.

    Google Scholar 

  23. Pelizzo MR, Piotto A, Beramasco A, Rubello D, Casara D. Parathyroid carcinoma. Therapeutic strategies derived from 20 years of experience. Minerva Endocrinol. 2001;26:23–9.

    PubMed  CAS  Google Scholar 

  24. Sanchez SA, Iglesias AMA. Diagnostic-therapeutic management of parathyroid carcinoma. An Med Interna. 2002;9:644–8.

    Google Scholar 

  25. Chow E, Tsang RW, Brierley JD, Filice S. Parathyroid carcinoma—the Princess Margaret Hospital experience. Int J Radiat Oncol Biol Phys. 1998;41:569–72.

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

V. R. Zivaljevic, R. V. Zivic, A. Dj. Diklic, B. R. Bukvic, S. B. Tatic, M. R. Kazic, N. K. Kalezic, and I. R. Paunovic declare that there is no conflict of interest.

Author information

Authors and Affiliations

  1. Centre for Endocrine Surgery, Institute for Endocrinology, Clinical Centre of Serbia, Dr. Koste Todorovica 8, Belgrade, Serbia

    V. R. Zivaljevic PhD, A. Dj. Diklic PhD, B. R. Bukvic MD & I. R. Paunovic PhD

  2. Surgery Clinic, Clinical Centre “Dr. Dragisa Misovic – Dedinje”, Milana Tepica 1, 11000, Belgrade, Serbia

    R. V. Zivic MD

  3. Institute of Pathological Anatomy, Medical Faculty, University of Belgrade, Dr Subotica 1, Belgrade, Serbia

    S. B. Tatic PhD

  4. Institute for Anesthesiology and Reanimation, Clinical Centre of Serbia, Pasterova 2, Belgrade, Serbia

    M. R. Kazic MD & N. K. Kalezic PhD

Authors
  1. V. R. Zivaljevic PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. V. Zivic MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Dj. Diklic PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. R. Bukvic MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. B. Tatic PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. R. Kazic MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. N. K. Kalezic PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. I. R. Paunovic PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. V. Zivic MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zivaljevic, V., Zivic, R., Diklic, A. et al. Parathyroid carcinoma in primary hyperparathyroidism: single institution experience. Eur Surg 44, 394–399 (2012). https://doi.org/10.1007/s10353-012-0180-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10353-012-0180-x

Keywords

Search

Navigation