Skip to main content
SpringerLink
Log in

QuEChERS with Magnetic Hydrophilic–Lipophilic Balanced Adsorbent and Its Application in Multi-Class Veterinary Residues in Milk by Ultra High-Performance Liquid Chromatography-Tandem Mass Spectrometry

  • Original
  • Published:
Chromatographia Aims and scope Submit manuscript

Abstract

Using magnetic hydrophilic–lipophilic balanced adsorbent (HLB), with divinylbenzene n-vinylpyrrolidone polymer as monomers and Fe3O4@C nanoparticles as magnetic material, a modified quick, easy, cheap, effective, rugged and safe (QuEChERS) method is proposed for veterinary residue analysis in milk. The magnetic Fe3O4@C-HLB adsorbent was fabricated via simple co-mixing method based on an “aggregate wrap” mechanism, which enabled magnetic solid-phase extraction. Thus, the resultant material can be separated from the solvent rapidly and conveniently by a magnet. The residues of regulatory interest in milk include β-lactams, aminoglyside, and macrolides. The analytes were quantified by ultra high-performance liquid chromatography coupled to an electrospray ionization tandem mass spectrometer operating in multiple reaction monitoring modes. The decision limit (CCα) was 0.1–0.8 µg/L, and the detection capability (CCβ) was 0.2–2 µg/L. The method was accurate with recoveries ranging from 70.5 to 98%. Good intra-precision and intermediate precision were obtained with RSD better than 10%.

Graphical Abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Yahaya N, Mitome T, Nishiyama N, Sanagi MM, Ibrahim WAW, Nur H (2013) J Pharm Innov 8(4):240–246

    Article  Google Scholar 

  2. Martínez-Huélamo M, Jiménez-Gámez E, Hermo MP, Barrón D, Barbosa J (2009) J Sep Sci 32:2385–2392

    Article  Google Scholar 

  3. Hermo MP, Nemutlu E, Kir S, Barrón D, Barbosa J (2008) Anal Chem Acta 613:98–105

    Article  CAS  Google Scholar 

  4. Christodoulou EA, Samanidou V (2007) J Sep Sci 30:2421–2429

    Article  CAS  Google Scholar 

  5. Kantiani L, Farré M, Sibum M, Postigo C, López de Alda M, Barceló D (2009) Anal Chem 81:4285–4292

    Article  CAS  Google Scholar 

  6. Han RW, Zheng N, Yu ZN, Wang J, Xu XM, Qu XY, Li SL, Zhang YD, Wang JQ (2015) Food Chem 181:119–126

    Article  CAS  Google Scholar 

  7. Zhan J, Yu XJ, Zhong YY, Zhang ZT, Cui XM, Peng JF, Feng R, Liu XT, Zhu Y (2012) J Chromatogr B 906:48–57

    Article  CAS  Google Scholar 

  8. Wang J, Leung D, Chow W, Chang J, Wong JW (2015) J Agric Food Chem 63(41):9175–9187

    Article  CAS  Google Scholar 

  9. Zhang Y, Li X, Liu X, Zhang J, Cao Y, Shi Z, Sun H (2015) J Dairy Sci 98(12):8433–8444

    Article  CAS  Google Scholar 

  10. Stubbings G, Bigwood T (2009) Anal Chim Acta 637:68–75

    Article  CAS  Google Scholar 

  11. Aguilera-Luiz MM, Vidal JLM, Romer-Gonzalez R (2008) J Chromatogr A 1205:10–18

    Article  CAS  Google Scholar 

  12. Socas-Rodríguez B, Lanková D, Urbancová K, Krtková V, Hernández-Borges J, Rodríguez-Delgado MÁ, Pulkrabová J, Hajšlová J (2017) Anal Bioanal Chem 409(18):4467–4477

    Article  Google Scholar 

  13. Zhou W, Ling Y, Liu T, Zhang Y, Li J, Li H, Wu W, Jiang S, Feng F, Yuan F, Zhang F (2017) J Chromatogr B 1061–1062:411–420

    Article  Google Scholar 

  14. Tuzimski T, Rejczak T (2017) J AOAC Int. https://doi.org/10.5740/jaoacint.17-0213

    Google Scholar 

  15. Rejczak T, Tuzimski T (2017) Food Chem 217:225–233

    Article  CAS  Google Scholar 

  16. Zhao PY, Wang L, Zhou L, Zhang FZ, Kang S, Pan CP (2012) J Chromatogr A 122:17–25

    Article  Google Scholar 

  17. Shen CY, Cao XW, Shen WJ, Jiang Y, Zhao ZY, Wu B, Yu KY, Liu H, Lian HZ (2011) Talanta 84:141–148

    Article  CAS  Google Scholar 

  18. Gilbert-Lopez B, Garcia-Reyes JF, Lozano A, Fernandez-Alba AR, Molina-Diaz A (2010) J Chromatogr A 1217:6022–6034

    Article  CAS  Google Scholar 

  19. Srivastava AK, Trivedi P, Srivastava MK, Lohani M, Srivastava LP (2011) Environ Monit Assess 176:465–473

    Article  CAS  Google Scholar 

  20. Correia-Sa L, Fernandes VC, Calhau C, Domingues VF, Delerue-Matos C (2013) Food Anal Methods 6:587–593

    Article  Google Scholar 

  21. Liu HC, Lin X, Lin T, Zhang YL, Luo YL, Li QW (2016) J Sep Sci 39:3594–3601

    Article  CAS  Google Scholar 

  22. Zhang XL, Niu HY, Pan YY, Shi YL, Cai YQ (2010) Anal Chem 82:2363–2371

    Article  CAS  Google Scholar 

  23. Sun L, Sun X, Du XB, Yue YS, Chen LG, Xu HY, Zeng QL, Wang H, Ding L (2010) Anal Chim Acta 665:185–192

    Article  CAS  Google Scholar 

  24. Ibarra IS, Rodriguez JA, Miranda JM, Vega M, Barrado E (2011) J Chromatograph A 1218:2196–2202

    Article  CAS  Google Scholar 

  25. Berrada H, Borrull F, Font G, Molto JC, Marce RM (2007) J Chromatogr A 1157:281–288

    Article  CAS  Google Scholar 

  26. Posyniak A, Zmudzki J, Mitrowska K (2005) J Chromatogr A 1087:259–264

    Article  CAS  Google Scholar 

  27. Romero-Gonzalez R, Lopez-Martinez JC, Gomez-Milan E, Garrido-Frenich A, Martinez-Vidal JL (2007) J Chromatogr B 857:142–148

    Article  CAS  Google Scholar 

  28. Kaufmann A, Butcher P, Maden K, Widmer M (2008) J Chromatogr A 1194:66–79

    Article  CAS  Google Scholar 

  29. Babin Y, Fortier S (2007) J AOAC Int 90:1418–1426

    CAS  Google Scholar 

  30. van Holthoon FL, Essers ML, Mulder PJ, Stead SL, Caldow M, Ashwin HM, Sharman M (2009) Anal Chim Acta 637:135–143

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by Projection 2013RA012 (social development projection of Yunnan province), 2014DA001, 2015HC025 (talent plan and scientific innovation platform of Yunnan province).

Author information

Authors and Affiliations

  1. Supervision and Testing Center for Farm Product Quality, Ministry of Agriculture, Kunming, People’s Republic of China

    Hongcheng Liu, Tao Lin, Xin Lin, Jinliang Shao & Qiwan Li

  2. Laboratory of Quality and Safety Risk Assessment for Agro-Product, Ministry of Agriculture, Kunming, People’s Republic of China

    Hongcheng Liu, Tao Lin, Xin Lin, Jinliang Shao & Qiwan Li

  3. Institute of Quality Standard and Testing Technology, Yunnan Academy of Agriculture Science, Kunming Xufu Road, Kunming, 650223, Yunnan, People’s Republic of China

    Hongcheng Liu, Tao Lin, Xin Lin, Jinliang Shao & Qiwan Li

Authors
  1. Hongcheng Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tao Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xin Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jinliang Shao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Qiwan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Qiwan Li.

Ethics declarations

Conflict of interest

All Authors declare that we have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, H., Lin, T., Lin, X. et al. QuEChERS with Magnetic Hydrophilic–Lipophilic Balanced Adsorbent and Its Application in Multi-Class Veterinary Residues in Milk by Ultra High-Performance Liquid Chromatography-Tandem Mass Spectrometry. Chromatographia 81, 265–275 (2018). https://doi.org/10.1007/s10337-017-3433-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10337-017-3433-9

Keywords

Search

Navigation