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Effect of Functionalized Stationary Phases on the Mechanism of Retention of Fungicides in RP-LC Elution

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Abstract

The objectives of this study were to investigate the molecular mechanisms of retention of selected fungicides and to classify stationary phases used for RP-HPLC. Chromatographic measurements were made using eight physicochemically diverse HPLC columns which were evaluated for analysis of nine biologically active compounds (strobilurins and triazoles). QSRRs were derived for the logarithms of the retention factors normalized to a hypothetical zero percent organic modifier in the mobile phase, log k W. Structural descriptors of the pesticides were used to describe their chromatographic retention behaviour under the given LC conditions. The next step was the correlation between retention data, log k W, and the structural descriptors of the analytes from molecular modelling.

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Acknowledgments

This work is supported by the European Social Fund, the Polish National Budget, and the Kujawsko-pomorskie Vovidship Budget—“Stypendia dla doktorantów 2008/2009-ZPORR”. Financial support from Foundation for Polish Science Professor’s Subsidy “Mistrz” is gratefully acknowledged.

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Authors and Affiliations

  1. Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin Street, 87-100, Toruń, Poland

    Sylwia Noga & Bogusław Buszewski

  2. Plant Protection Institute, Pesticide Residue Laboratory, 20 W Węgorka Street, 60-318, Poznan, Poland

    Monika Michel

Authors
  1. Sylwia Noga
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  2. Monika Michel
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  3. Bogusław Buszewski
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Correspondence to Bogusław Buszewski.

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Noga, S., Michel, M. & Buszewski, B. Effect of Functionalized Stationary Phases on the Mechanism of Retention of Fungicides in RP-LC Elution. Chromatographia 73, 857–864 (2011). https://doi.org/10.1007/s10337-011-1931-8

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  • DOI: https://doi.org/10.1007/s10337-011-1931-8

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