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Renal BOLD MRI in patients with chronic kidney disease: comparison of the semi-automated twelve layer concentric objects (TLCO) and manual ROI methods

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Abstract

Objective

Blood oxygenation level dependent (BOLD) MRI technique is used to evaluate changes in intra-renal oxygenation in chronic kidney disease (CKD). The purpose of this study was to evaluate if the novel twelve layer concentric objects (TLCO) method has advantages over the manually defined regions of interest (ROI) analysis.

Methods and materials

Existing renal BOLD MRI data acquired before and after furosemide on a 3 T scanner from 41 CKD patients and 13 age matched healthy controls were analyzed using TLCO method and compared with previously reported ROI analysis.

Results

Regional R2* measurements were strongly correlated between the two methods, while ΔR2* was moderately correlated. Medullary R2* by ROI analysis showed higher values compared to R2*_Inner by TLCO, probably due to the contributions from the cortex to R2*_Inner. R2*_Slope and Δ(R2*_Slope), unique parameters based on the TLCO method provided the most significant differences between stage 3a CKD patients and controls and were correlated with eGFR.

Discussion

There was a high degree of agreement between the two methods in terms of regional R2* measurements and both methods did not show differences between moderate CKD patients and controls. However, R2*_Slope and Δ(R2*_Slope) showed the largest sensitivity in distinguishing CKD from controls.

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Acknowledgement

Work supported in part by Grant from the National Institute of Diabetes Digestive and Kidney Diseases R01-DK093793.

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Authors and Affiliations

  1. NorthShore University HealthSystem, 2650 Ridge Avenue, Walgreen Jr. Building, Suite G507, Evanston, IL, 60201, USA

    Lu-Ping Li, Stuart Sprague, Bradley Hack & Pottumarthi Prasad

  2. Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

    Bastien Milani & Menno Pruijm

  3. University of Chicago Medical Center, University of Chicago, Chicago, USA

    Orly Kohn

Authors
  1. Lu-Ping Li
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  2. Bastien Milani
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  3. Menno Pruijm
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  4. Orly Kohn
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  5. Stuart Sprague
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  6. Bradley Hack
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  7. Pottumarthi Prasad
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Contributions

Authors’ contribution will be based on the following contribution area. PP: Study conception and design. LLP, OK, and SS: Acquisition of data. LLP, BM, MP, BH, and PP: Analysis and interpretation of data. LLP, BH, and PP: Drafting of manuscript. LLP, BM, MP, BH, PP: Critical revision.

Corresponding author

Correspondence to Pottumarthi Prasad.

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None of the authors had any conflict of interest to disclose with regards to the content of the manuscript.

Ethical standards

The Research involved Human participants. All procedures were performed with approval from the institutional review boards (at NorthShore University HealthSystem and University of Chicago), and written subject consent prior to enrollment.

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Li, LP., Milani, B., Pruijm, M. et al. Renal BOLD MRI in patients with chronic kidney disease: comparison of the semi-automated twelve layer concentric objects (TLCO) and manual ROI methods. Magn Reson Mater Phy 33, 113–120 (2020). https://doi.org/10.1007/s10334-019-00808-5

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  • DOI: https://doi.org/10.1007/s10334-019-00808-5

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