Abstract
Objective
The aim of our study was to compare the risk of main postoperative complications of patients underwent total thyroidectomy (TT), near total thyroidectomy (NTT) and subtotal thyroidectomy (ST) for treating BMNG.
Methods
Electronic databases including Cochrane Controlled Trials Register, EMbase, Medline, SCI Expanded-ISI, NTIS, SIGLE and CNKI were searched. Eligible studies were randomized controlled trials which compared the incidence of postoperative complications of TT with ST/NTT for treating BMNG. Data extraction was using predefined data fields and assessment of methodological quality with the GRADE approach. A Mantel-Haenszel random-effects model was used and the effect sizes were expressed by using relative risks and 95% confidence intervals.
Results
Four studies including 881 participants that met inclusion criteria were analyzed. Compared with ST/NTT, TT was associated with increased risk of transient RLNI (recurrent laryngeal nerve injuries) (relative risk 2.18, 95% confidence interval 1.08 to 4.42; P < 0.05) and transient hypocalcemia (3.79, 1.64 to 8.77; P < 0.05), but there were no statistically significant differences in permanent RLNI (1.36, 0.31 to 6.02; P > 0.05) and permanent hypocalcemia (2.37, 0.35 to 15.97; P > 0.05). The quality of evidence for each individual outcome was ultimately rated as moderate (permanent RLNI and permanent hypocalcemia), low (transient RLNI and transient hypocalcemia).
Conclusion
For treating BMNG with thyroidectomy, there were no statistically significant differences in postoperative complications between TT and ST/NTT on a long view.
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Si, P., Xu, Y., Tu, Y. et al. Compare the postoperative complications incidence of benign multi-nodular goiter: A meta-analysis. Chin. -Ger. J. Clin. Oncol. 11, 575–580 (2012). https://doi.org/10.1007/s10330-012-1032-7
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DOI: https://doi.org/10.1007/s10330-012-1032-7